Marginal Bone Loss Around Dental Implants and Its Association with Chronic Corticosteroid Use: A Prospective Cohort Study.

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Maxillofacial & Oral Surgery Pub Date : 2025-08-01 Epub Date: 2025-06-02 DOI:10.1007/s12663-025-02608-y

Reza Tabrizi, Hediyeh Koohi, Shima Moradian-Lotfi, Ensiyeh Cheraghchibashi Astaneh, Mahsa Davarpanah, Samir Aboul Hosn Centenero

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引用次数: 0

Abstract

Background: Prolonged corticosteroid use leads to glucocorticoid-induced osteoporosis.

Objective: This study aimed to assess marginal bone loss around dental implants in patients with chronic corticosteroid use.

Methodology: This prospective cohort study included patients who required dental implant therapy on the posterior maxilla and mandible with a history of chronic corticosteroid use (12 months or longer). A control group was considered without corticosteroids to compare marginal bone loss (MBL). The implants were loaded with cemented restorative crowns 4 months after placement. Radiographs were obtained immediately after loading and 12 months later. The vertical distance between the shoulder of the implant and the highest point of the surrounding alveolar bone was defined as the initial marginal bone surface. The use of chronic corticosteroids (12 months or more) is the primary predictive factor. Marginal bone loss (MBL) was the study's primary outcome, defined as the difference between the reference point and the new marginal bone level after 12 months. The study covariates included age, gender, implant sites, corticosteroid dose, and gingival type (thick or thin).

Results: In total, 154 subjects (75 cases and 79 controls) were included in our study. The mean age was 45.33 ± 10.44 and 43.37 ± 10.07 among the cases and controls, respectively (p-value = 0.237), and the mean corticosteroid dosage was 6.43 ± 2.50. Among the cases, 68% (n = 51) had bone type III, and 32% (n = 24) had bone type IV. Among the control group, 40.50% (n = 32), 58.22% (n = 46), and 1.26% (n = 1) had bone types IV, III, and II, respectively. We found a significant correlation between MBL and corticosteroid use in both the mandible (Pearson's correlation = 0.921, p-value < 0.001) and maxilla (Pearson's correlation = 0.871, p-value < 0.001).

Conclusion: The study results revealed a dose-response relationship between marginal bone loss and corticosteroid use, suggesting that prolonged corticosteroid use increases the risk of implant failure.

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种植体周围边缘骨质流失及其与慢性皮质类固醇使用的关系：一项前瞻性队列研究。

背景：长期使用糖皮质激素可导致糖皮质激素诱导的骨质疏松症。目的：本研究旨在评估长期使用皮质类固醇患者种植体周围的边缘骨质流失。方法：这项前瞻性队列研究纳入了有慢性皮质类固醇使用史（12个月或更长时间）的患者，这些患者需要在后上颌和下颌骨种植牙。对照组不使用皮质类固醇来比较边际骨质流失（MBL）。植入4个月后，植入骨水泥修复冠。装药后立即和12个月后拍x线片。将种植体肩部与周围牙槽骨最高点之间的垂直距离定义为初始边缘骨面。使用慢性皮质类固醇（12个月或更长时间）是主要的预测因素。边缘骨损失（MBL）是研究的主要结果，定义为参考点与12个月后新的边缘骨水平之间的差异。研究的协变量包括年龄、性别、种植部位、皮质类固醇剂量和牙龈类型（厚或薄）。结果：本研究共纳入154名受试者（75例，79例对照）。患者和对照组的平均年龄分别为45.33±10.44岁和43.37±10.07岁（p值= 0.237），平均皮质类固醇剂量为6.43±2.50。其中III型占68% (n = 51)， IV型占32% (n = 24)，对照组中IV型占40.50% (n = 32)， III型占58.22% (n = 46)， II型占1.26% （n = 1）。我们发现MBL与下颌骨皮质类固醇使用之间存在显著相关性（Pearson’s correlation = 0.921， p值p值）。结论：研究结果显示边缘骨质流失与皮质类固醇使用之间存在剂量-反应关系，提示长期使用皮质类固醇会增加种植体失败的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Maxillofacial & Oral Surgery DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

1.90

自引率

0.00%

发文量

138

期刊介绍： This journal offers comprehensive coverage of new techniques, important developments and innovative ideas in Oral and Maxillofacial Surgery. Practice-applicable articles help develop the methods used to handle dentoalveolar surgery, facial injuries and deformities, TMJ disorders, oral cancer, jaw reconstruction, anesthesia and analgesia. The journal also includes specifics on new instruments, diagnostic equipment’s and modern therapeutic drugs and devices. Journal of Oral and Maxillofacial Surgery is recommended for first or priority subscription by the Dental Section of the Medical Library Association. Specific topics covered recently have included: ? distraction osteogenesis ? synthetic bone substitutes ? fibroblast growth factors ? fetal wound healing ? skull base surgery ? computer-assisted surgery ? vascularized bone grafts Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.