Increased Propofol Sensitivity Associated With Hearing Loss in Patients Undergoing Vestibular Schwannoma Surgery: A Retrospective Study.

IF 2.4 2区医学 Q2 ANESTHESIOLOGY

Journal of neurosurgical anesthesiology Pub Date : 2025-08-04 DOI:10.1097/ANA.0000000000001054

Xuehua Zhou, Yiru Wang, Songyuan Chi, Guo Ran, Kaizheng Chen, Xia Shen

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引用次数: 0

Abstract

Background: Propofol is widely used in neurosurgery, with its dosage typically based on patient weight and variability. While factors like age, sex, and cognitive function are known to influence propofol requirements, the impact of preoperative hearing function remains underexplored. This study investigates the relationship between hearing loss and propofol sensitivity in vestibular schwannoma surgery patients.

Methods: This retrospective study analyzed 475 patients who underwent vestibular schwannoma resection between May 12, 2020, and February 28, 2024. Total intravenous anesthesia (TIVA) with propofol and remifentanil was used, maintaining BIS values between 40 and 60. Hearing impairment was defined as a pure tone average (PTA) ≥20 dB. Multivariable linear regression was used to assess the relationship between preoperative hearing function and propofol requirements.

Results: The hearing-impaired group was older (51.7±10.5 vs. 42.9±10.5 y, P<0.001) and required lower median (IQR) propofol doses (96.7 [85.2 to 115.2] vs. 109.0 [91.4 to 126.9] μg·kg-1·min-1, 95% CI: 5.511-15.016, P<0.001). In unadjusted analysis, hearing loss (PTA ≥20 dB) was associated with reduced propofol requirements (OR: -10.4, P<0.001). This association remained significant in multivariable analysis adjusting for age, sex, ASA, BMI, and anesthesia provider (ORadj: -5.0; 95% CI: -9.8 to -0.2; P=0.040).

Conclusion: Hearing loss is associated with increased propofol sensitivity in vestibular schwannoma surgery, highlighting its potential relevance in anesthesia management.

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前庭神经鞘瘤手术患者异丙酚敏感性增加与听力损失相关：一项回顾性研究。

背景：异丙酚广泛应用于神经外科，其剂量通常基于患者体重和可变性。虽然已知年龄、性别和认知功能等因素会影响异丙酚的需用，但术前听力功能的影响仍未得到充分研究。本研究探讨前庭神经鞘瘤手术患者听力损失与异丙酚敏感性的关系。方法：本回顾性研究分析了2020年5月12日至2024年2月28日期间接受前庭神经鞘瘤切除术的475例患者。使用异丙酚和瑞芬太尼全静脉麻醉（TIVA），维持BIS值在40 ~ 60之间。以纯音平均值(PTA)≥20 dB为听力障碍。采用多变量线性回归评估术前听力功能与异丙酚需用量之间的关系。结果：听力受损组患者年龄较大（51.7±10.5岁vs 42.9±10.5岁）。结论：听力损失与前庭神经鞘瘤手术中异丙酚敏感性增加有关，强调其与麻醉管理的潜在相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of neurosurgical anesthesiology 医学-临床神经学

CiteScore

6.20

自引率

10.80%

发文量

119

审稿时长

>12 weeks

期刊介绍： The Journal of Neurosurgical Anesthesiology (JNA) is a peer-reviewed publication directed to an audience of neuroanesthesiologists, neurosurgeons, neurosurgical monitoring specialists, neurosurgical support staff, and Neurosurgical Intensive Care Unit personnel. The journal publishes original peer-reviewed studies in the form of Clinical Investigations, Laboratory Investigations, Clinical Reports, Review Articles, Journal Club synopses of current literature from related journals, presentation of Points of View on controversial issues, Book Reviews, Correspondence, and Abstracts from affiliated neuroanesthesiology societies. JNA is the Official Journal of the Society for Neuroscience in Anesthesiology and Critical Care, the Neuroanaesthesia and Critical Care Society of Great Britain and Ireland, the Association de Neuro-Anesthésiologie Réanimation de langue Française, the Wissenschaftlicher Arbeitskreis Neuroanästhesie der Deutschen Gesellschaft fur Anästhesiologie und Intensivmedizen, the Arbeitsgemeinschaft Deutschsprachiger Neuroanästhesisten und Neuro-Intensivmediziner, the Korean Society of Neuroanesthesia, the Japanese Society of Neuroanesthesia and Critical Care, the Neuroanesthesiology Chapter of the Colegio Mexicano de Anesthesiología, the Indian Society of Neuroanesthesiology and Critical Care, and the Thai Society for Neuroanesthesia.