The influence of 179 lipid metabolism on head and neck cancer is mediated by 91 inflammatory factors.

IF 0.9 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Community dental health Pub Date : 2025-06-01 Epub Date: 2025-06-26 DOI:10.1177/0265539X251343832

Shaoqi Hua, Tingyu Lang, Ruimin Liu

引用次数: 0

Abstract

Background: Head and neck cancer (HNC) is influenced by lipids and inflammatory factors. This study explores the causal relationship between 179 lipids, 91 inflammatory factors, and HNC using Mendelian Randomization (MR) analysis.

Method: GWAS datasets for lipids and inflammatory markers were combined with HNC data from the FinnGen Biobank. TSMR and MVMR analyses with multiple sensitivity methods were performed to validate results. Mediator analysis identified inflammatory factors as intermediaries in lipid-HNC pathways.

Results: Eight lipids were causally associated with HNC. Two distinct pathways were identified: inflammatory markers CD244, FLT3LG, and NT-3 mediated the relationship between lipids (e.g., sterol esters, phosphatidylcholines) and HNC.

Conclusion: This study identifies lipids and inflammatory markers as key mediators of HNC development, offering potential diagnostic and therapeutic targets for future research.

查看原文本刊更多论文

179脂质代谢对头颈癌的影响是由91种炎症因子介导的。

背景：头颈癌（HNC）受脂质和炎症因子的影响。本研究利用孟德尔随机化（MR）分析探讨了179种脂质、91种炎症因子与HNC之间的因果关系。方法：脂质和炎症标志物的GWAS数据集与FinnGen Biobank的HNC数据相结合。采用多灵敏度方法进行TSMR和MVMR分析以验证结果。中介分析确定炎症因子是脂质- hnc通路的中介。结果：8种脂质与HNC有因果关系。我们确定了两种不同的途径：炎症标志物CD244、FLT3LG和NT-3介导了脂质（如甾醇酯、磷脂酰胆碱）和HNC之间的关系。结论：本研究确定了脂质和炎症标志物是HNC发展的关键介质，为未来的研究提供了潜在的诊断和治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Community dental health 医学-牙科与口腔外科

CiteScore

2.20

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is concerned with dental public health and related subjects. Dental public health is the science and the art of preventing oral disease, promoting oral health, and improving the quality of life through the organised efforts of society. The discipline covers a wide range and includes such topics as: -oral epidemiology- oral health services research- preventive dentistry - especially in relation to communities- oral health education and promotion- clinical research - with particular emphasis on the care of special groups- behavioural sciences related to dentistry- decision theory- quality of life- risk analysis- ethics and oral health economics- quality assessment. The journal publishes scientific articles on the relevant fields, review articles, discussion papers, news items, and editorials. It is of interest to dentists working in dental public health and to other professionals concerned with disease prevention, health service planning, and health promotion throughout the world. In the case of epidemiology of oral diseases the Journal prioritises national studies unless local studies have major methodological innovations or information of particular interest.