Causality between periodontitis and schizophrenia, bipolar disorder, and major depressive disorder: A mendelian randomization study.

IF 0.9 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Community dental health Pub Date : 2025-06-01 Epub Date: 2025-06-27 DOI:10.1177/0265539X251351451

Shimin Zhang, Jingning Mao, Guocheng Mei, Jiaxuan Liu, Yuxiao Huang, Renchuan Tao, Lanlan Jiang

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引用次数: 0

Abstract

Background: Increasing evidence suggests that periodontitis (PD) is epidemiologically associated with mental health. To minimize the influence of confounding factors, we employed Mendelian randomization (MR) as the analytical approach to investigate the potential causal relationships between PD and schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD).

Methods: 8 single nucleotide polymorphisms (SNPs), sourced from a genome-wide association study (GWAS) of 45,563 individuals were used as instrumental variables for PD. 131, 52 and 0 SNPs were employed from 3 GWASs of SZ, BD and MDD, respectively. We took inverse variance-weighted model as the primary method for causal estimation supplemented by MR-Egger and Weighted-median. Then we conducted sensitivity analysis and leave-one-out analysis.

Results: Periodontitis is the risk factor of BD (OR = 1.10; P = 0.0086). However, no significant causal association was observed between PD and SZ (OR = 1.03; P = 0.5045) or MDD (OR = 1.06; P = 0.1089). Neither SZ (OR = 1.01; P = 0.6763), BD (OR = 1.06; P = 0.2070) nor MDD was associated with PD.

Conclusions: Our analysis supports previous epidemiological findings by showing a potential causal association between PD and BD; whereas, no causal link of PD with SZ or MDD, and SZ, BD or MDD with PD. These offers novel concepts for the diagnosis and treatment.

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牙周炎与精神分裂症、双相情感障碍和重度抑郁症之间的因果关系：一项孟德尔随机研究。

背景：越来越多的证据表明牙周炎（PD）在流行病学上与心理健康有关。为了尽量减少混杂因素的影响，我们采用孟德尔随机化（MR）作为分析方法来研究PD与精神分裂症（SZ）、双相情感障碍（BD）和重度抑郁症（MDD）之间的潜在因果关系。方法：从45,563个个体的全基因组关联研究（GWAS）中获得的8个单核苷酸多态性（snp）作为PD的工具变量。从SZ、BD和MDD的3个GWASs中分别检测到131、52和0个snp。我们以方差加权逆模型作为因果估计的主要方法，并辅以MR-Egger和加权中位数。然后进行敏感性分析和留一分析。结果：牙周炎是BD的危险因素(OR = 1.10；P = 0.0086)。然而，PD与SZ之间没有显著的因果关系(OR = 1.03；P = 0.5045)或MDD (or = 1.06；P = 0.1089)。SZ (OR = 1.01；P = 0.6763), bd (or = 1.06；P = 0.2070)， MDD与PD无关。结论：我们的分析支持先前的流行病学发现，显示PD和双相障碍之间存在潜在的因果关系；PD与SZ或MDD、SZ、BD或MDD与PD无因果关系。这为诊断和治疗提供了新的概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Community dental health 医学-牙科与口腔外科

CiteScore

2.20

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is concerned with dental public health and related subjects. Dental public health is the science and the art of preventing oral disease, promoting oral health, and improving the quality of life through the organised efforts of society. The discipline covers a wide range and includes such topics as: -oral epidemiology- oral health services research- preventive dentistry - especially in relation to communities- oral health education and promotion- clinical research - with particular emphasis on the care of special groups- behavioural sciences related to dentistry- decision theory- quality of life- risk analysis- ethics and oral health economics- quality assessment. The journal publishes scientific articles on the relevant fields, review articles, discussion papers, news items, and editorials. It is of interest to dentists working in dental public health and to other professionals concerned with disease prevention, health service planning, and health promotion throughout the world. In the case of epidemiology of oral diseases the Journal prioritises national studies unless local studies have major methodological innovations or information of particular interest.