Influence of Immune Cells and Circulating Inflammatory Cytokines on Pathological Scars: A Mendelian Randomization Study.

IF 2.2 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-07-29 eCollection Date: 2025-01-01 DOI:10.2147/CCID.S532061

Yang Xu, Weisheng Zhan, Juhua Zhao

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Abstract

Background: Pathological scars are the products of abnormal repair during the wound healing process. Previous researches have demonstrated that immune cells and inflammatory cytokines are closely associated with pathological scars. However, the causality between immune cells, inflammatory cytokines and pathological scars remains unclear.

Methods: After obtaining genome-wide association studies (GWAS) data on immune cells, cytokines, hypertrophic scars, and keloids, we selected appropriate single - nucleotide polymorphisms (SNPs) for Mendelian randomization (MR) analysis. The inverse-variance weighted (IVW) method was used as the main analytical method. Sensitivity analyses were conducted to evaluate reliability of research findings.

Results: Our research results indicated that 10 immunophenotypes can increase risk of hypertrophic scars, 5 immunophenotypes can decrease risk of hypertrophic scars, 3 inflammatory cytokines can increase risk of hypertrophic scars, and 2 inflammatory cytokines can decrease risk of hypertrophic scars. Meanwhile, 5 immunophenotypes can increase risk of keloids, 4 immunophenotypes can decrease risk of keloids, 1 inflammatory cytokine can increase risk of keloids, and 1 inflammatory cytokine can decrease risk of keloids.

Conclusion: This study reveals the roles of immune phenotypes and cytokines in the pathogenesis of pathological scars, and provides valuable references in research areas such as early identification and intervention treatment of pathological scars.

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免疫细胞和循环炎性细胞因子对病理性疤痕的影响：孟德尔随机研究。

背景：病理性瘢痕是创面愈合过程中异常修复的产物。以往的研究表明，免疫细胞和炎性细胞因子与病理性瘢痕密切相关。然而，免疫细胞、炎症细胞因子与病理性疤痕之间的因果关系尚不清楚。方法：在获得免疫细胞、细胞因子、增生性疤痕和瘢痕疙瘩的全基因组关联研究（GWAS）数据后，我们选择合适的单核苷酸多态性（snp）进行孟德尔随机化（MR）分析。采用反方差加权法（IVW）作为主要分析方法。采用敏感性分析评价研究结果的可靠性。结果：我们的研究结果表明，10种免疫表型可增加增生性瘢痕的风险，5种免疫表型可降低增生性瘢痕的风险，3种炎症因子可增加增生性瘢痕的风险，2种炎症因子可降低增生性瘢痕的风险。同时，5种免疫表型可增加瘢痕疙瘩风险，4种免疫表型可降低瘢痕疙瘩风险，1种炎症细胞因子可增加瘢痕疙瘩风险，1种炎症细胞因子可降低瘢痕疙瘩风险。结论：本研究揭示了免疫表型和细胞因子在病理性瘢痕发病机制中的作用，为病理性瘢痕的早期识别和干预治疗等研究领域提供了有价值的参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.