Evaluation of Gastric Peristalsis Using Cine MRI in Healthy Subjects and Patients With Functional Dyspepsia.

IF 3 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinical and Translational Gastroenterology Pub Date : 2025-09-01 DOI:10.14309/ctg.0000000000000900

Shotaro Oki, Tsutomu Takeda, Mariko Hojo, Shunsuke Nakamura, Takuya Kanazawa, Momoko Yamamoto, Tomoyo Iwano, Hisanori Utsunomiya, Ryota Uchida, Daiki Abe, Nobuyuki Suzuki, Atsushi Ikeda, Yoichi Akazawa, Kumiko Ueda, Hiroya Ueyama, Tomoyoshi Shibuya, Shuko Nojiri, Daisuke Asaoka, Andrea Todisco, Shuji Sato, Ryohei Kuwatsuru, Akihito Nagahara

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引用次数: 0

Abstract

Introduction: Functional dyspepsia (FD) is subdivided into postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS), each with a different pathophysiological mechanisms driving the symptoms of these syndromes. Cine MRI aids observation in any continuous cross-section and measures gastrointestinal peristalsis without radiation exposure. In this study, we aimed to evaluate gastric peristalsis in FD using cine MRI.

Methods: This study was a prospective interventional study. Patients diagnosed with FD according to ROME IV diagnostic criteria were included. Cine MRI was performed before and after the test meal. Gastric maximum short axis diameter, amplitude, contraction frequency, peristaltic wave height, peristaltic wave velocity, and gastric motility index were evaluated and compared between healthy control (HC) and patients with FD (PDS/EPS).

Results: This study consisted of 18 HC and 31 patients with FD (including 22 with PDS and 9 with EPS). Preprandial comparison of the HC, PDS, and EPS groups showed no significant difference. Postprandial comparison of the 3 groups showed significant differences in maximum short axis diameter of fornix (HC: 51.5 ± 9.1/PDS: 47.1 ± 10.3/EPS: 59.0 ± 13.6 mm, P = 0.045), amplitude of fornix (HC: 7.3 ± 5.1/PDS: 12.1 ± 4.3/EPS: 11.3 ± 8.7 mm, P = 0.009), contraction frequency (HC: 2.9 ± 0.3/PDS: 2.7 ± 0.5/EPS: 2.6 ± 0.2 times/min, P = 0.007), peristaltic wave height (HC: 14.9 ± 4.0/PDS: 9.2 ± 2.5/EPS: 9.5 ± 3.2 mm, P < 0.001), and gastric motility index (HC: 24.5 ± 7.1/PDS: 16.8 ± 6.1/EPS: 15.9 ± 6.3 mm 2 /s, P = 0.002).

Discussion: Cine MRI can be used to visually evaluate gastric peristalsis dysfunction and impaired gastric accommodation in FD.

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在健康受试者和功能性消化不良患者中应用电影MRI评价胃蠕动。

功能性消化不良（FD）又分为餐后窘迫综合征（PDS）和胃脘痛综合征（EPS），每一种症状都有不同的病理生理机制驱动。在没有辐射照射的情况下，电影MRI可以在任何连续的横截面上观察和测量胃肠道蠕动。在这项研究中，我们的目的是利用电影MRI来评估FD中的胃蠕动。方法：本研究为前瞻性介入研究。纳入根据ROME IV诊断标准诊断为FD的患者。在试餐前后分别行MRI检查。比较健康对照（HC）和FD （PDS/ EPS）患者胃最大短轴直径、振幅、收缩频率、蠕动波高度、蠕动波速度和胃动力指数（GMI）。结果：本研究纳入18例HC和31例FD患者（其中PDS 22例，EPS 9例）。HC组、PDS组和EPS组餐前比较无显著差异。餐后比较三组在穹窿最大短轴直径（HC: 51.5±9.1/ PDS: 47.1±10.3/ EPS: 59.0±13.6 mm, p=0.045）、穹窿振幅（HC: 7.3±5.1/ PDS: 12.1±4.3/ EPS: 11.3±8.7 mm, p=0.009）、收缩频率（HC: 2.9±0.3/ PDS: 2.7±0.5/ EPS: 2.6±0.2次/min， p=0.007）、蠕动波高度（HC: 14.9±4.0/ PDS: 9.2±2.5/ EPS: 9.5±3.2 mm, p=0.007）均有显著差异。MRI可直观评价FD患者胃蠕动功能障碍和胃调节功能受损。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.00

自引率

0.00%

发文量

114

审稿时长

16 weeks

期刊介绍： Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.