Dietary and Circulating Vitamins, Polymorphisms of Vitamin Metabolism Genes, and the Risk of Gastrointestinal Cancers: A Systematic Review and Meta-Analysis.

IF 3 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinical and Translational Gastroenterology Pub Date : 2025-09-01 DOI:10.14309/ctg.0000000000000899

Xin-Ling Wang, Heng-Min Xu, Zhi-Qiang Hu, Kai-Feng Pan, Wen-Qing Li

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引用次数: 0

Abstract

Introduction: Vitamin intake may reduce gastrointestinal cancer risk, but how genetic polymorphisms in vitamin metabolism affect this association remains unclarified. This meta-analysis examined whether genetic polymorphisms in vitamin metabolism influence the association between dietary and circulating vitamins and the risk of gastrointestinal cancers.

Methods: Literature search was conducted to gather studies investigating the associations between vitamins, genetic polymorphisms, and gastrointestinal cancer risk. Statistical analyses were conducted using "meta" package in R.

Results: Our meta-analysis incorporated 64 studies on colorectal cancer (CRC), gastric cancer, and esophageal cancer, focusing on vitamin B and vitamin D. High dietary intake of vitamin B was significantly associated with reduced gastrointestinal cancer risk (odds ratio [OR] 0.84, 95% confidence interval [CI] 0.79-0.90), as was its circulating level (OR 0.53, 95% CI 0.36-0.78). Individuals harboring the MTHFR 1298 AA/AC and CC genotypes demonstrated varying association of CRC risk with dietary vitamin B intake ( P -het = 0.04), whereas the significant inverse association of circulating vitamin B with CRC risk was found only for MTHFR 677 TT carriers (OR 0.57, 95% CI 0.33-0.97), but not for the CC/CT genotype (OR 0.98, 95% CI 0.80-1.21, P -het = 0.06). High dietary (OR 0.69, 95% CI 0.53-0.90) and circulating vitamin D levels (OR 0.74, 95% CI 0.59-0.94) significantly lowered gastrointestinal cancer risk. The inverse association between circulating vitamin D and CRC risk was exclusively yielded for VDR TaqI Tt/tt carriers (OR 0.52, 95% CI 0.28-0.95), other than the TT genotype (OR 0.91, 95% CI 0.70-1.19, P -het = 0.10).

Discussion: High dietary and circulating vitamin B and vitamin D levels were associated with lowered gastrointestinal cancer risk, and the associations may be modified by certain genetic variations in vitamin metabolism pathways.

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膳食和循环维生素，维生素代谢基因多态性，和胃肠道癌症的风险：系统回顾和荟萃分析。

目的：维生素摄入可能降低胃肠道癌症风险，但维生素代谢遗传多态性如何影响这种关联尚不清楚。这项荟萃分析研究了维生素代谢遗传多态性是否影响饮食和循环维生素与胃肠道癌症风险之间的关系。方法：进行文献检索，收集有关维生素、遗传多态性和胃肠道癌症风险之间关系的研究。结果：我们的荟萃分析纳入了64项关于结直肠癌（CRC）、胃癌和食管癌的研究，重点关注维生素B和维生素d。高维生素B饮食摄入量与降低胃肠道癌症风险显著相关（优势比[OR]=0.84, 95%可信区间[CI]: 0.79-0.90），维生素B循环水平也与之显著相关（OR=0.53, 95%可信区间[CI]: 0.36-0.78）。携带MTHFR 1298AA/AC和CC基因型的个体显示出CRC风险与饮食维生素B摄入量的不同相关性（P-het=0.04），而循环维生素B与CRC风险的显著负相关仅在MTHFR 677TT携带者中发现（OR=0.57, 95%CI: 0.33-0.97），而在CC/CT基因型中没有发现（OR=0.98, 95%CI: 0.80-1.21, P-het=0.06）。高饮食（OR=0.69, 95%CI: 0.53-0.90）和循环维生素D水平（OR=0.74, 95%CI: 0.59-0.94）显著降低了胃肠道癌症的风险。除了Tt基因型（OR=0.91, 95%CI: 0.70-1.19, p - et=0.10）外，循环维生素D与结直肠癌风险之间的负相关仅在VDR TaqI Tt/ Tt携带者中得到证实（OR=0.52, 95%CI: 0.28-0.95）。结论：高饮食和循环维生素B和维生素D水平与降低胃肠道癌症风险相关，这种关联可能与维生素代谢途径的某些遗传变异有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.00

自引率

0.00%

发文量

114

审稿时长

16 weeks

期刊介绍： Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.