Demystify Carbapenem-resistant Acinetobacter baumannii Pneumonia Burden: 2-Year Cohort Study.

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL

Annals of African Medicine Pub Date : 2025-08-04 DOI:10.4103/aam.aam_304_24

Alfian Nur Rosyid, Pepy Dwi Endraswari, Firman Setiawan, Yessy Puspitasari, Tri Pudy Asmarawati, Brian Eka Rachman, Arina Dery Puspitasari, Ahmad Mufid Sultoni, Prastuti Asta Wulaningrum

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引用次数: 0

Abstract

Introduction: The World Health Organization has identified carbapenem-resistant Acinetobacter baumannii (CRAB) infections as the most important pathogens for which new antibiotics must be developed immediately. Therefore, this study aimed to analyze the comparison of epidemiology, microbial pattern, and antibiotic resistance in CRAB and carbapenem-sensitive A. baumannii (CSAB).

Methods: A retrospective cohort study was used, with community-acquired pneumonia with A. baumannii bacterial culture results. Data were obtained from the patient's medical record and the results of antibiotic sensitivity testing with the culture method by planting sputum on blood agar and MacConkey medium for 24 h.

Results: A total of 50 patients, CRAB (n = 26) and CSAB (n = 24), found that the average gender was male in CRAB compared to CSAB (69.2% vs. 48.2%). Complications of respiratory failure, sepsis, and acute respiratory distress syndrome were higher in CRAB compared to CSAB (30.8% vs. 20.8%, 46.2% vs. 25%, and 2% vs. 0%). The mortality rate in the CRAB group was 53.8% vs. CSAB 12.5%. The mean length of stay (LOS) in CRAB was 17.92, while CSAB was 11.00. The mean cost of hospitalization in CRAB was higher than CSAB ($6993.0615 vs. $3263.7375). The mean neutrophil-to-lymphocyte ratio value in the CRAB group was 20.4, while in CSAB was 10.6.

Conclusions: The results indicated that CRAB infection carries a greater burden in terms of cost of treatment, mortality, LOS, and more serious complications, compared to CSAB infection.

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揭秘耐碳青霉烯鲍曼不动杆菌肺炎负担：2年队列研究。

世界卫生组织已经确定耐碳青霉烯鲍曼不动杆菌（CRAB）感染是最重要的病原体，必须立即开发新的抗生素。因此，本研究旨在分析螃蟹和碳青霉烯敏感鲍曼不动杆菌（CSAB）的流行病学、微生物模式和耐药性的比较。方法：采用回顾性队列研究，观察社区获得性肺炎伴鲍曼不整杆菌培养结果。结果：50例患者，螃蟹（n = 26）和CSAB (n = 24)，螃蟹和CSAB的平均性别为男性，螃蟹和CSAB的平均性别为男性（69.2%比48.2%）。与CSAB相比，CRAB组呼吸衰竭、败血症和急性呼吸窘迫综合征的并发症更高（30.8% vs. 20.8%, 46.2% vs. 25%, 2% vs. 0%）。CRAB组死亡率为53.8%，CSAB组为12.5%。CRAB组平均住院时间（LOS）为17.92，CSAB组平均住院时间为11.00。CRAB组的平均住院费用高于CSAB组（6993.0615美元比3263.7375美元）。螃蟹组中性粒细胞/淋巴细胞比值平均值为20.4，而CSAB组为10.6。结论：结果表明，与CSAB感染相比，螃蟹感染在治疗费用、死亡率、LOS和更严重的并发症方面负担更大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of African Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The Annals of African Medicine is published by the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria and the Annals of African Medicine Society. The Journal is intended to serve as a medium for the publication of research findings in the broad field of Medicine in Africa and other developing countries, and elsewhere which have relevance to Africa. It will serve as a source of information on the state of the art of Medicine in Africa, for continuing education for doctors in Africa and other developing countries, and also for the publication of meetings and conferences. The journal will publish articles I any field of Medicine and other fields which have relevance or implications for Medicine.