Clinical characteristics and survival outcome of vulvar cancer in South Korea: A nationwide study from the Cancer Public Library Database

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-08-04 DOI:10.1111/jog.70029

Chel Hun Choi, Ha kyun Chang, Gi Hwan Bae, Jong Ha Hwang

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引用次数: 0

Abstract

Objective

Vulvar cancer, although rare, presents clinical challenges due to diverse histological subtypes and varying prognoses. This study aimed to examine the clinical characteristics and survival outcomes of vulvar cancer in South Korea.

Methods

A retrospective cohort study was conducted using data from the Cancer Public Library Database, which includes information from the Korea National Cancer Incidence Database, Statistics Korea, and National Health Insurance databases. The study analyzed data from South Korean women diagnosed with vulvar cancer between 2014 and 2016.

Results

Out of 1242 initial patients, 292 met the inclusion criteria. The untreated group (n = 62) had a higher proportion of patients aged 80 and above (35.5%) and a higher mean Charlson Comorbidity Index (CCI) score compared to the treatment group (n = 230). The treatment group showed significantly higher survival probability (adjusted HR 0.358, 95% CI: 0.24–0.54) compared to the untreated group. Surgical intervention alone reduced mortality risk significantly (adjusted HR 0.20, 95% CI: 0.12–0.33), particularly among those diagnosed at an earlier clinical stage. Histologically, basal cell carcinoma had the highest survival probability with a significantly lower mortality risk than squamous cell carcinoma (adjusted HR 0.11, 95% CI: 0.02–0.82). Adenocarcinoma also showed improved survival outcomes (adjusted HR 0.42, 95% CI: 0.19–0.94).

Conclusion

The study emphasizes the importance of early diagnosis and surgical treatment in improving survival outcomes for vulvar cancer patients. It also highlights the need to consider demographic and clinical factors in treatment planning and calls for region-specific studies to address unique epidemiological patterns.

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韩国外阴癌的临床特征和生存结果：一项来自癌症公共图书馆数据库的全国性研究

目的外阴癌虽然罕见，但由于其不同的组织学亚型和不同的预后，给临床带来了挑战。本研究旨在探讨韩国外阴癌的临床特征和生存结果。方法采用癌症公共图书馆数据库的数据进行回顾性队列研究，其中包括来自韩国国家癌症发病率数据库、韩国统计局和国民健康保险数据库的信息。该研究分析了2014年至2016年间被诊断患有外阴癌的韩国女性的数据。结果1242例首发患者中，292例符合纳入标准。与治疗组（n = 230）相比，未治疗组（n = 62） 80岁及以上患者比例（35.5%）和Charlson共病指数（CCI）平均得分更高。治疗组的生存率明显高于未治疗组（调整后危险度0.358,95% CI: 0.24-0.54）。单纯的手术干预可显著降低死亡风险（校正HR 0.20, 95% CI: 0.12-0.33），尤其是在早期临床阶段确诊的患者。组织学上，基底细胞癌的生存率最高，死亡风险显著低于鳞状细胞癌（校正HR 0.11, 95% CI: 0.02-0.82）。腺癌也显示出改善的生存结果（调整后危险度0.42,95% CI: 0.19-0.94）。结论本研究强调了早期诊断和手术治疗对提高外阴癌患者生存预后的重要性。它还强调需要在治疗规划中考虑人口和临床因素，并呼吁进行针对特定区域的研究，以处理独特的流行病学模式。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.