Serum TP53TG1 Serves as a Diagnostic Biomarker for Sepsis and Has a Predictive Value for Clinical Outcomes

Abstract

To investigate the diagnostic value of the lncRNA TP53TG1 in sepsis and its ability to predict clinical outcomes, 121 sepsis patients and 115 healthy controls were enrolled. RT-qPCR measured TP53TG1 expression, and the ROC curve assessed its diagnostic value. Pearson correlation analyzed correlations between TP53TG1 and inflammatory factors, APACHE II score, and SOFA score. Cox regression assessed the risk factors for 28-day mortality, and Kaplan–Meier survival analysis evaluated the effect of TP53TG1 levels on mortality in patients. TP53TG1 was downregulated in patients, with 79.34% sensitivity and 80.00% specificity for differentiating patients from healthy controls. The TP53TG1 level was negatively correlated with PCT, CRP, IL-6, TNF-α, WBC, Scr, AST, PT, lactate, the APACHE II score, and the SOFA score, but positively correlated with ALB. Additionally, TP53TG1 and the SOFA score were identified as risk factors influencing the 28-day survival of patients, and a decrease in TP53TG1 expression was significantly associated with reduced survival rates. This study showed that TP53TG1 can serve as a biomarker for the diagnosis of sepsis and is closely associated with disease severity and inflammatory responses.