Numerical estimates of GABA immunoreactive neurons in the human lateral geniculate nucleus in the prenatal period.

Human neurobiology Pub Date : 1988-01-01
S Wadhwa, J Takács, V Bijlani, J Hámori
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Abstract

Quantitative analysis has been performed on Nissl stained and gamma-aminobutyric acid (GABA) immunoreactive neurons in the lateral geniculate nucleus (LGN) of human fetuses ranging from 8 to 37 weeks of gestation. Total cell density in the LGN increases from 8 to 12 weeks of gestation with a subsequent decline continuously up to 37 weeks. No GABA immunoreactive neurons are visualized in the LGN of 8 and 12 weeks fetuses. At 15-16 weeks of gestation 1% of neurons are immunostained. A peak rise is seen to occur at 17 weeks when 16% cells are GABA immunopositive. However, at 19 weeks there is an equally sharp decline in the percentage of GABA neurons to 4%. Subsequently, with the continued reduction in overall numerical density the percentage of GABA neurons remains relatively constant but rises again to 5% at 26 weeks. On making quantitative estimations of numerical density and percentage of GABA neurons separately for the prospective magno- and parvocellular regions in the early age periods from 15-16 to 21 weeks as well as at 22-23 weeks, when magnocellular laminae begin to segregate, and at 26 weeks when distinct laminae are present, it is observed that the magnocellular regions have a higher density and percentage of GABA neurons at all the gestational ages in comparison to the parvocellular region. With increasing gestational age, non-GABA neurons gradually increase in size with marked growth of magnocellular neurons at 26 weeks. The GABA neurons, on the other hand, have an almost constant size up to 19 weeks and start growing from 21 weeks onwards. The GABA neurons tend to be larger in the magno- than in parvocellular regions at all gestational ages studied.

产前期人外侧膝状核中GABA免疫反应神经元的数值估计。
定量分析了8 ~ 37周妊娠人膝状外侧核(LGN)的尼氏染色和γ -氨基丁酸(GABA)免疫反应神经元。妊娠8 ~ 12周,LGN总细胞密度增加,随后持续下降至37周。8周和12周胎儿LGN未见GABA免疫反应神经元。妊娠15-16周时,1%的神经元免疫染色。在第17周出现峰值,16%的细胞呈GABA免疫阳性。然而,在19周时,GABA神经元的比例同样急剧下降至4%。随后,随着总体数值密度的持续降低,GABA神经元的百分比保持相对恒定,但在26周时再次上升至5%。通过对15-16 ~ 21周、22-23周(大细胞层开始分离)和26周(不同层存在)的大细胞区和旁细胞区的GABA神经元数量密度和百分比分别进行定量估计,观察到与旁细胞区相比,大细胞区在所有胎龄均具有更高的GABA神经元密度和百分比。随着胎龄的增加,非gaba神经元的大小逐渐增加,大细胞神经元在26周时明显增加。另一方面,GABA神经元在19周内几乎保持不变,从21周开始生长。在所有的孕龄研究中,伽马氨基丁酸神经元在马脑区比在旁细胞区更大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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