Comparison of intralesional triamcinolone acetonide alone and with 5-fluorouracil for the treatment of keloids.

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Journal of the Pakistan Medical Association Pub Date : 2025-07-01 DOI:10.47391/JPMA.20767

Sadia Bhatti, Sadaf Ahmed Asim, Madiha Sajid, Tayyaba Iqbal, Fozia Shaikh, Hira Fatima Waseem

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引用次数: 0

Abstract

Objectives: To compare the efficacy of intralesional triamcinolone acetonide alone and in combination with 5 -fluorouracil in the management of keloids.

Methods: The prospective cross-sectional study was conducted at the Dermatology outpatient department, Ojha campus, Dow University of Health Sciences, Karachi, from April to September 2023, and comprised patients with keloids who were divided into group A receiving intralesional triamcinolone acetonide 40mg/ml alone, and group B receiving a combination of triamcinolone acetonide 40mg/ml and 5-fluorouracil 50mg/ml. The medication was given monthly for 6 months, and efficacy was assessed using the Vancouver Scar Scale on each visit before the injection. Data was analysed with SPSS version 26.

Results: Of the 66 patients, 33(50%) were in group A; 19(57.6%) females and 14(42.4%) males with mean age 34.39±9.81 years. There were 33(50%) patients in group B; 20(60.6%) females and 13(39.4%) males with mean age 33.75±11.51 years. In group B, good to excellent response was seen in 31 (95%) cases compared to 23 (70%) in group A. Side effects such as atrophy (3 cases, 9.1%) and telangiectasia (2 cases, 6.1%) were more prevalent in Group A compared to atrophy (1 case, 3%) and telangiectasia (1 case, 3%) in Group B.

Conclusion: Intralesional triamcinolone acetonide in combination with 5-fluorouracil was found to be more effective with faster response and less side-effects compared to triamcinolone acetonide alone.

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局部单独曲安奈德与5-氟尿嘧啶治疗瘢痕疙瘩的比较。

目的：比较曲安奈德单用与5 -氟尿嘧啶合用治疗瘢痕疙瘩的疗效。方法：前瞻性横断面研究于2023年4 - 9月在卡拉奇陶氏卫生科学大学Ojha校区皮肤科门诊进行，将瘢痕瘤患者分为单独使用曲安奈德40mg/ml的A组，曲安奈德40mg/ml和5-氟尿嘧啶50mg/ml联合使用的B组。每个月给药，持续6个月，注射前每次就诊时使用温哥华疤痕量表评估疗效。数据采用SPSS 26进行分析。结果：66例患者中，A组33例（50%）；女性19例（57.6%），男性14例（42.4%），平均年龄34.39±9.81岁。B组33例（50%）；女性20例（60.6%），男性13例（39.4%），平均年龄33.75±11.51岁。B组有31例（95%）反应良好至优良，A组有23例（70%）反应良好至优良。A组有萎缩3例（9.1%）、毛细血管扩张2例（6.1%），B组有萎缩1例（3%）、毛细血管扩张1例（3%）。结论：局部注射曲安奈德联合5-氟尿嘧啶比单用曲安奈德更有效，反应更快，副作用更小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Pakistan Medical Association Medicine-General Medicine

CiteScore

1.10

自引率

11.10%

发文量

983

审稿时长

3-6 weeks

期刊介绍： Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.