Beyond language: empathy and emotion recognition deficits in primary progressive aphasias

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical Pub Date : 2025-01-01 DOI:10.1016/j.nicl.2025.103852

Giulia Giacomucci , Alice Pieri , Valentina Moschini , Chiara Crucitti , Sonia Padiglioni , Carmen Morinelli , Giulia Galdo , Filippo Emiliani , Matilde Nerattini , Silvia Bagnoli , Assunta Ingannato , Sandro Sorbi , Benedetta Nacmias , Valentina Berti , Valentina Bessi

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引用次数: 0

Abstract

Although primary progressive aphasia (PPA) is considered a language disorder, increasing evidence points to the presence of social cognition impairments in PPA variants. The aims of this study were to explore empathy and emotion recognition deficits in the three PPA variants (sv-PPA, lv-PPA, nfv-PPA) and to identify their neural correlates.

Eleven sv-PPA, 34 lv-PPA,11 nfv-PPA patients and 34 healthy controls (HC) were included in this study. Empathy was explored with the Interpersonal Reactivity Index (IRI) (Perspective Taking – PT, Fantasy – FT, Empathic Concern – EC, Personal Distress – PD), rated by caregivers before (T0) and after (T1) the onset of cognitive symptoms. Emotion recognition was evaluated with the Ekman 60Faces (EK-60F) Test and metabolic activity with [18F]FDG-PET.

In all PPA variants, PT score was reduced from T0 to T1 (sv-PPA p = 0.014, lv-PPA p < 0.001, nfv-PPA p = 0.022) and PD score was increased (sv-PPA p = 0.033, lv-PPA p < 0.001, nfv-PPA p = 0.009). Only lv-PPA showed a decrease of FT score (p = 0.024), while EC was spared in all three variants. Sv-PPA patients had the worst performances in the EK-60F Test, followed by lv-PPA and, lastly, by nfv-PPA.

Correlations between EK-60F scores and metabolic activity were found in sv-PPA and lv-PPA, highlighting the involvement of areas participating in the emotion recognition network: cingulate cortex, insula, temporal and orbitofrontal cortices and inferior frontal gyrus.

All PPA variants exhibited impairments in cognitive empathy (PT) and heightened emotional contagion (PD). The most severe deficits in emotion recognition were shown by sv-PPA, while nfv-PPA was the less impaired variant.

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超越语言：原发性进行性失语症的移情和情绪识别缺陷。

虽然原发性进行性失语症（PPA）被认为是一种语言障碍，但越来越多的证据表明，PPA变体中存在社会认知障碍。本研究的目的是探讨三种PPA变体（sv-PPA、lv-PPA、nfv-PPA）的共情和情绪识别缺陷，并确定它们的神经相关性。svv - ppa患者11例，lv-PPA患者34例，nfv-PPA患者11例，健康对照34例。共情采用人际反应指数（IRI）（观点采取- PT，幻想- FT，共情关注- EC，个人困扰- PD），由照顾者在认知症状出现前（T0）和后（T1）评定。用Ekman 60Faces （EK-60F）测试评估情绪识别，用[18F]FDG-PET评估代谢活性。在所有PPA变异中，PT评分从T0降至T1 （sv-PPA p = 0.014, lv-PPA p = 0.014）

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroimage-Clinical NEUROIMAGING-

CiteScore

7.50

自引率

4.80%

发文量

368

审稿时长

52 days

期刊介绍： NeuroImage: Clinical, a journal of diseases, disorders and syndromes involving the Nervous System, provides a vehicle for communicating important advances in the study of abnormal structure-function relationships of the human nervous system based on imaging. The focus of NeuroImage: Clinical is on defining changes to the brain associated with primary neurologic and psychiatric diseases and disorders of the nervous system as well as behavioral syndromes and developmental conditions. The main criterion for judging papers is the extent of scientific advancement in the understanding of the pathophysiologic mechanisms of diseases and disorders, in identification of functional models that link clinical signs and symptoms with brain function and in the creation of image based tools applicable to a broad range of clinical needs including diagnosis, monitoring and tracking of illness, predicting therapeutic response and development of new treatments. Papers dealing with structure and function in animal models will also be considered if they reveal mechanisms that can be readily translated to human conditions.