Elevated alanine transaminase in liver transplant recipients after BNT162b2 vaccination: a cohort study.

IF 6.5 1区医学 Q1 IMMUNOLOGY

NPJ Vaccines Pub Date : 2025-08-02 DOI:10.1038/s41541-025-01233-7

Jacob Siewertsen Bergmann, Sebastian Rask Hamm, Louise Bering, Christian Ross Pedersen, Ask Bock, Safura-Luise Heidari, Gerda Elisabeth Villadsen, Annette Dam Fialla, Gro Linno Willemoe, Peter Holland-Fischer, Susanne Dam Nielsen

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Abstract

Liver transplant (LTx) recipients risk severe COVID-19. Vaccination reduces this risk. However, there may be side effects, including elevated alanine transaminase (ALT) which could lead to increased use of liver biopsy. We aimed to describe prevalence and relative incidence of elevated ALT 90 days before and after BNT162b2 vaccination in LTx recipients. Furthermore, we aimed to describe changes in prevalence of liver biopsies before and after BNT162b2 vaccination. We included 393 LTx recipients from The Danish Comorbidity in Liver Transplant Recipients (DACOLT) study. We calculated prevalence of elevated ALT and liver biopsies before and after each BNT162b2 vaccine dose. We used self-control case series (SCCS) analysis to investigate whether vaccination was associated with higher relative incidence of elevated ALT. Prevalence of elevated ALT, around each vaccine dose, was comparable. We did not find higher relative incidence of elevated ALT after vaccination. The prevalence of liver biopsies around vaccination was comparable.

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接种BNT162b2疫苗后肝移植受者丙氨酸转氨酶升高：一项队列研究

肝移植（LTx）受者有严重COVID-19的风险。接种疫苗可降低这种风险。然而，可能有副作用，包括谷丙转氨酶（ALT）升高，这可能导致肝活检的使用增加。我们的目的是描述LTx受者接种BNT162b2疫苗前后90天ALT升高的患病率和相对发生率。此外，我们旨在描述BNT162b2疫苗接种前后肝活检患病率的变化。我们纳入了来自丹麦肝移植受者合并症（DACOLT）研究的393名LTx受者。我们计算了每次BNT162b2疫苗接种前后ALT升高和肝活检的患病率。我们使用自我控制病例序列（SCCS）分析来调查疫苗接种是否与较高的ALT升高相对发生率相关。每次疫苗剂量前后ALT升高的发生率具有可比性。我们没有发现接种疫苗后ALT升高的相对发生率更高。接种前后肝活检的流行率是相当的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.