Pregnancy and obstetric outcomes of frozen-thawed embryo transfer with embryos generated from COVID‑19 infection during controlled ovarian stimulation: a retrospective study.
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引用次数: 0
Abstract
Purpose: This investigation aimed to explore the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during controlled ovarian stimulation (COS) on the pregnancy and obstetric outcomes in frozen-thawed embryo transfer (FET) cycles. This area has not been thoroughly examined in previous research.
Methods: This retrospective cohort study analyzed 126 couples with confirmed SARS-CoV-2 infection during COS and evaluated FET outcomes using embryos generated during virologically active exposure windows. Controls were noninfected women during COS, matched by age, number, and day of embryo transfer in the same time. Demographic and cycle characteristics and pregnancy and obstetric outcomes were examined for this retrospective cohort analysis.
Results: This cohort study comprised 300 infertile couples, stratified into SARS-CoV-2-exposed (n = 126) and unexposed (n = 174) groups based on infection status during COS. The clinical pregnancy rates were 58.8% and 58.6%, respectively (P = 0.958). Other pregnancy features, including biochemical pregnancy, early miscarriage, ongoing pregnancy, and cumulative clinical pregnancy, were also comparable between the two groups. No significant intergroup differences were observed in obstetric outcomes, such as gestational age, cesarean section rates, and preterm birth rates.
Conclusions: In FET cycles of patients with embryos generated from SARS-CoV-2 infection, no significant difference in pregnancy and obstetric outcomes was observed. These data substantiate the reproductive safety of FET following SARS-CoV-2 exposure during COS. Nevertheless, more studies are needed for longitudinal investigations to elucidate the transgenerational effects of SARS-CoV-2 on somatic maturation and neurodevelopmental trajectories in offspring.
期刊介绍：
The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species.
The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.
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