Cord blood chemokine levels as a predictor of oxidative stress and morbidities of prematurity

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-08-04 DOI:10.1016/j.cyto.2025.157006

Gozdem Kayki , Erdal Sag , Ferid Aliyev , Seza Ozen , Sule Yigit

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引用次数: 0

Abstract

Objective

Oxidative stress during the antenatal period causes an increase in the risk of morbidity and mortality in newborns. This study aimed to determine oxidative stress in the antenatal period, by measuring chemokine levels in cord blood and to show the correlation between chemokine levels and prematurity morbidities.

Methods

Neonates born at or below 32 weeks of gestation at Hacettepe University Ihsan Dogramaci Children's Hospital or Ordu University Training and Research Hospital were included in the study. Cord blood samples were collected and IL-8, IP-10, eotaxin, TARC, MCP-1, MIP-1α, MIG, ENA-78, MIP-3α, GROα, I-TAC, MIP-1β levels were measured. Morbidities of prematurity [respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), patent ductus arteriosus (PDA), intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL), necrotizing enterocolitis (NEC) and retinopathy of prematurity (ROP)] and mortality/discharge status were collected via the hospital records. Diagnosis was noted and their relationship with cord blood chemokine levels was examined.

Results

Total 55 patients with a mean gestational age of 29 weeks (±3) and a mean birth weight of 1303 (±479) grams were included in the study. IL-8 levels were significantly higher in cord blood samples from babies diagnosed with RDS, BPD, PDA, IVH, PVL, ROP and mortality. Elevated MIP-3α levels were associated with BPD, PDA, NEC, IVH, ROP, and mortality, while increased MIP-1β levels were observed in cases of RDS, BPD, and ROP. When the participants were divided into three groups according to their gestational age, a statistically significant increase in IL-8 (p < 0.001), MIP-3α (p = 0.004) and MIP-1β (p = 0.016) levels was found as gestational age decreased.

Conclusion

Cord blood chemokine levels including IL-8, MIP-3α, and MIP-1β may serve as potential biomarkers for identifying infants at risk of prematurity-related morbidities. However, since these levels also vary with gestational age, their interpretation requires caution. Larger studies are needed to validate these findings.

Abstract Image

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脐带血趋化因子水平作为氧化应激和早产发病率的预测因子。

目的：产前氧化应激可增加新生儿的发病率和死亡率。本研究旨在通过测量脐带血中的趋化因子水平来确定产前氧化应激，并显示趋化因子水平与早产发病率之间的相关性。方法：在Hacettepe大学Ihsan Dogramaci儿童医院或Ordu大学培训与研究医院出生的妊娠32周及以下的新生儿纳入研究。采集脐带血样本，检测IL-8、IP-10、eotaxin、TARC、MCP-1、MIP-1α、MIG、ENA-78、MIP-3α、GROα、I-TAC、MIP-1β水平。通过医院记录收集早产儿[呼吸窘迫综合征（RDS）、支气管肺发育不良（BPD）、动脉导管未闭（PDA）、脑室内出血（IVH）、脑室周围白质软化（PVL）、坏死性小肠结肠炎（NEC）和早产儿视网膜病变（ROP）]的发病率和死亡率/出院情况。记录诊断并检查其与脐带血趋化因子水平的关系。结果：55例平均胎龄为29周（±3），平均出生体重为1303（±479）g的患者被纳入研究。诊断为RDS、BPD、PDA、IVH、PVL、ROP和死亡率的婴儿的脐带血样本中IL-8水平显著升高。MIP-3α水平升高与BPD、PDA、NEC、IVH、ROP和死亡率相关，而MIP-1β水平升高与RDS、BPD和ROP有关。当参与者根据胎龄分为三组时，IL-8水平有统计学意义的增加(p)结论：脐带血趋化因子水平包括IL-8、MIP-3α和MIP-1β可能作为识别早产儿相关疾病风险的潜在生物标志物。然而，由于这些水平也随胎龄而变化，因此对它们的解释需要谨慎。需要更大规模的研究来验证这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.