A 2-year calorie restriction intervention may reduce glycomic biological age biomarkers - a pilot study.

IF 6 Q2 GERIATRICS & GERONTOLOGY

npj aging Pub Date : 2025-08-01 DOI:10.1038/s41514-025-00254-9

Tea Pribić, Jayanta K Das, Lovorka Đerek, Daniel W Belsky, Melissa Orenduff, Kim M Huffman, William E Kraus, Helena Deriš, Jelena Šimunović, Tamara Štambuk, Azra Frkatović-Hodžić, Virginia B Kraus, Sai Krupa Das, Susan B Racette, Nirad Banskota, Luigi Ferrucci, Carl Pieper, Nathan E Lewis, Gordan Lauc, Sridevi Krishnan

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Abstract

In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants (n = 26) were evaluated for the effects of 2 years of 25% calorie restriction (CR) on N-glycosylation of IgG, plasma, and complement C3, as well as IgG-based biological age (GlycAge). Plasma samples were collected at baseline (BL), 12 (12mo), and 24 months (24mo). IgG galactosylation was higher at 24mo compared to BL (p = 0.051) and increased from 12mo to 24mo (p = 0.016); GlycAge decreased over the same period (p = 0.027). GlycAge was positively associated with TNF-α (p = 0.030) and ICAM-1 (p = 0.017). Between BL and 24mo, plasma high-branched glycans declined (p = 0.013), bisecting GlcNAcs increased in both plasma (p < 0.001) and IgG (p = 0.01), complement C3 protein (p < 0.001), C3-Man9 (p < 0.001), and C3-Man9Glc1C3 (p = 0.046) were reduced. The absence of a control group warrants cautious interpretation.

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一项初步研究表明，2年的卡路里限制干预可能会降低糖糖生物年龄生物标志物。

在这项试点研究中，CALERIE二期的一个子集(No。NCT00427193，注册于2007年1月25日)的参与者（n = 26）被评估了2年25%卡路里限制（CR）对IgG、血浆和补体C3的n -糖基化以及基于IgG的生物年龄（GlycAge）的影响。分别在基线（BL）、12个月（12mo）和24个月（24mo）采集血浆样本。与BL相比，IgG半乳糖基化在24mo时较高（p = 0.051），在12mo至24mo期间升高（p = 0.016）；GlycAge在同一时期下降（p = 0.027）。GlycAge与TNF-α (p = 0.030)和ICAM-1 （p = 0.017）呈正相关。在BL和24mo之间，血浆中高支聚糖下降（p = 0.013），两种血浆中分切GlcNAcs增加（p = 0.013）

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来源期刊

npj aging

CiteScore

8.90

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0.00%

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