From fragment to form: whole-body regeneration in a model urochordate.

IF 6.5 1区医学 Q1 CELL & TISSUE ENGINEERING

npj Regenerative Medicine Pub Date : 2025-08-01 DOI:10.1038/s41536-025-00423-0

Yuval Rinkevich, Baruch Rinkevich

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Abstract

Tissue and organ regeneration are common among aquatic invertebrates, yet these taxa and their potential as model organisms remain underexplored. We present evidence of extensive regenerative capabilities in aquatic invertebrates, highlighting examples of whole-body regeneration (WBR), a peak form of regeneration, where entire organisms regenerate from minute body fragments. Among the many examples of WBR, we focus on botryllid ascidians, an intriguing group of invertebrate chordates that display chordate tissue complexity while demonstrating WBR from small fragments of blood vessels. Centering on WBR in the model species Botrylloides leachi, we outline shared characteristics of WBR across botryllid ascidians including the presence of circulating multipotent stem cells, systemic induction processes, and ensuing competition among regeneration sites, culminating in the restoration of a complete organism. This regeneration mode is distinct from those in mammals and humans. Further research may offer valuable insights into mechanisms by which tissue fragments reinstate new organisms.

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从碎片到形态：尾脊索动物模型的全身再生。

组织和器官再生在水生无脊椎动物中很常见，但这些分类群及其作为模式生物的潜力仍未得到充分探索。我们提出了水生无脊椎动物广泛再生能力的证据，重点介绍了全身再生（WBR）的例子，这是再生的一种高峰形式，整个生物体从微小的身体碎片中再生。在许多WBR的例子中，我们关注的是botryllid海鞘，这是一组有趣的无脊椎脊索动物，它们显示出脊索动物组织的复杂性，同时从血管的小碎片中展示WBR。以模式物种bottryloides leachi的WBR为中心，我们概述了botryloides asciids WBR的共同特征，包括循环多能干细胞的存在、系统诱导过程和随后再生位点之间的竞争，最终恢复了一个完整的生物体。这种再生模式不同于哺乳动物和人类。进一步的研究可能为组织碎片恢复新生物体的机制提供有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Regenerative Medicine Engineering-Biomedical Engineering

CiteScore

10.00

自引率

1.40%

发文量

审稿时长

12 weeks

期刊介绍： Regenerative Medicine, an innovative online-only journal, aims to advance research in the field of repairing and regenerating damaged tissues and organs within the human body. As a part of the prestigious Nature Partner Journals series and in partnership with ARMI, this high-quality, open access journal serves as a platform for scientists to explore effective therapies that harness the body's natural regenerative capabilities. With a focus on understanding the fundamental mechanisms of tissue damage and regeneration, npj Regenerative Medicine actively encourages studies that bridge the gap between basic research and clinical tissue repair strategies.