Infant gut microbiota and SCFAs mediate the association between early-life human milk microbiota and neurodevelopment.

IF 9.2 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2025-08-01 DOI:10.1038/s41522-025-00790-y

Simou Wu, Wen Jia, Jinxing Li, Yating Luo, Fei Chen, Ting Yang, Xia Jiang, Fang He, Ruyue Cheng

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Abstract

Human milk microbiota (HMM) plays a key role in infant gut microbiota (IGM) establishment, however, the influence of the early life HMM in later neurodevelopment remains unclear. In this mother-infant cohort, we investigated HMM development and its impact on IGM-neurodevelopment crosstalk. Breast milk and infant feces were collected on days 0, 7, and 30 for sequencing and SCFAs quantification, while neurodevelopment was assessed via ASQ-3 at 12 months. HMM remained stable during the first month, while IGM fluctuated significantly within the first 7 days. Songbird and mediation analyses revealed strengthening associations between HMM, IGM, and neurodevelopment over time. IGM served as a key mediator linking HMM to neurodevelopment, with SCFAs playing a mediating role in the connection between IGM and neurodevelopment on day 30. Our findings suggest that early-life stable and unique HMM may influence long-term neurodevelopment by dynamically modulating IGM and SCFAs, highlighting a potential strategy to prevent neurodysplasia by monitoring mother-infant microecology.

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婴儿肠道微生物群和SCFAs介导早期母乳微生物群与神经发育之间的关联。

母乳微生物群（HMM）在婴儿肠道微生物群（IGM）的建立中起着关键作用，然而，早期生命HMM对后期神经发育的影响尚不清楚。在这个母婴队列中，我们研究了HMM的发展及其对igm -神经发育串扰的影响。在第0、7和30天收集母乳和婴儿粪便进行测序和scfa定量，并在12个月时通过ASQ-3评估神经发育。HMM在第一个月保持稳定，而IGM在前7天内波动明显。鸣禽和中介分析揭示了HMM、IGM和神经发育之间的联系随着时间的推移而增强。IGM是连接HMM与神经发育的关键介质，而scfa在第30天IGM与神经发育之间的连接中发挥中介作用。我们的研究结果表明，生命早期稳定和独特的HMM可能通过动态调节IGM和scfa来影响长期的神经发育，强调了通过监测母婴微生态来预防神经发育不良的潜在策略。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.