Neurodegeneration in Parkinson's disease: are we looking at the right spot?

IF 2.9 3区 医学 Q2 NEUROSCIENCES
Gabriel S Rocha, Marco Aurelio M Freire, Daniel Falcao, Tiago F Outeiro, Rafael R Lima, Jose Ronaldo Santos
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引用次数: 0

Abstract

Parkinson's disease (PD) is recognized as the fastest-growing neurodegenerative disorder, impacting millions of individuals worldwide. It is primarily characterized by cardinal motor symptoms, including bradykinesia (slowness of movement), tremor, rigidity, and postural instability, which significantly impair the quality of life of those affected. Traditionally, the prevailing hypothesis has attributed these motor symptoms to the degeneration and subsequent loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Currently, emerging research suggests that this neuron-centric view may be overly simplistic and not entirely accurate. In light of this, growing attention has turned to the role of axons within the nigrostriatal pathway-an extensive network connecting the substantia nigra to the striatum, essential for both dopamine transmission and the overall functioning of the motor control by the brain. By directing a focus toward this aspect, in this nano review article we examine why nigrostriatal axons deserve increased attention and should be considered a pivotal target for further therapeutic strategies in PD.

Abstract Image

帕金森氏症的神经退化:我们找对地方了吗?
帕金森病(PD)被认为是增长最快的神经退行性疾病,影响着全世界数百万人。它的主要特征是主要的运动症状,包括运动迟缓(运动缓慢)、震颤、僵硬和姿势不稳定,这严重损害了患者的生活质量。传统上,流行的假设将这些运动症状归因于黑质致密部(SNpc)多巴胺能神经元的退化和随后的丧失。目前,新兴的研究表明,这种以神经元为中心的观点可能过于简单,并不完全准确。鉴于此,越来越多的注意力转向了轴突在黑质纹状体通路中的作用,这是一个连接黑质和纹状体的广泛网络,对多巴胺的传递和大脑运动控制的整体功能都至关重要。通过将焦点指向这方面,在这篇纳米综述文章中,我们研究了为什么黑质纹状体轴突值得更多的关注,并应被视为PD进一步治疗策略的关键靶点。
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来源期刊
Molecular Brain
Molecular Brain NEUROSCIENCES-
CiteScore
7.30
自引率
0.00%
发文量
97
审稿时长
>12 weeks
期刊介绍: Molecular Brain is an open access, peer-reviewed journal that considers manuscripts on all aspects of studies on the nervous system at the molecular, cellular, and systems level providing a forum for scientists to communicate their findings. Molecular brain research is a rapidly expanding research field in which integrative approaches at the genetic, molecular, cellular and synaptic levels yield key information about the physiological and pathological brain. These studies involve the use of a wide range of modern techniques in molecular biology, genomics, proteomics, imaging and electrophysiology.
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