Interaction between the non-alcoholic fatty liver disease fibrosis score and vitamin D deficiency on left ventricular hypertrophy and impaired diastolic function in patients with type 2 diabetes mellitus.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetology & Metabolic Syndrome Pub Date : 2025-08-01 DOI:10.1186/s13098-025-01808-3

Yun-Ming Li, Jia-Yi Huang, Ran Guo, Shi-Ming Li, Cong Chen, Min Wu, Run Wang, Ming-Ya Liu, Kai-Hang Yiu

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引用次数: 0

Abstract

Aims: The present study aimed to evaluate the effect of Non-Alcoholic Fatty Liver Disease Fibrosis Score (NFS), vitamin D deficiency, and their interaction on the Left Ventricle (LV) structure and diastolic function in type 2 diabetes mellitus (T2DM) patients.

Methods: A total of 595 T2DM patients were recruited and stratified according to NFS grades (low, intermediate, and high) and the level of serum 25(OH)D (with and without vitamin D deficiency). Parameters of LV structure and diastolic dysfunction were measured by echocardiography. The association between NFS and LV structure and diastolic function was assessed using multivariable linear regression models stratified by vitamin D levels.

Results: Left ventricular hypertrophy (LVH) was more prevalent in patients with high NFS compared to those with low and intermediate NFS (41.0 vs 14.0% and 9.0%, P < 0.001). The average E/e' was higher in patients with intermediate and high NFS, as compared to those with low NFS. Within the high NFS group, patients with vitamin D deficiency exhibited significantly higher left ventricular mass index (LVMI) and average E/e' compared to those without vitamin D deficiency. An interaction between vitamin D and NFS groups was found on both LVMI (P for interaction = 0.008) and average E/e' (P for interaction = 0.001).

Conclusions: NFS and vitamin D deficiency are associated with an increased risk of LVH and impaired diastolic function in patients with T2DM. Notably, the impact of vitamin D deficiency on these parameters is more pronounced in individuals with a high NFS score.

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非酒精性脂肪肝纤维化评分与维生素D缺乏对2型糖尿病患者左室肥厚和舒张功能损害的相互作用

目的：本研究旨在评估非酒精性脂肪性肝病纤维化评分（NFS）、维生素D缺乏及其相互作用对2型糖尿病（T2DM）患者左心室（LV）结构和舒张功能的影响。方法：共招募595例T2DM患者，并根据NFS分级（低、中、高）和血清25(OH)D水平（伴有和不伴有维生素D缺乏症）进行分层。超声心动图测定左室结构参数及舒张功能障碍。NFS与左室结构和舒张功能之间的关系通过维生素D水平分层的多变量线性回归模型进行评估。结果：与低NFS和中度NFS患者相比，高NFS患者左心室肥厚（LVH）更为普遍（41.0 vs 14.0%和9.0%）。结论：NFS和维生素D缺乏与T2DM患者LVH和舒张功能受损的风险增加相关。值得注意的是，维生素D缺乏对这些参数的影响在NFS评分较高的个体中更为明显。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

6.20

自引率

0.00%

发文量

170

审稿时长

7.5 months

期刊介绍： Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.