Physical exercise prevents behavioral and neurobiological deficits induced by sleep deprivation in rodents through the regulation of BDNF and 5-HT Levels: A systematic review and meta-analysis.

IF 2.3 3区 心理学 Q2 BEHAVIORAL SCIENCES
Behavioural Brain Research Pub Date : 2025-10-18 Epub Date: 2025-07-30 DOI:10.1016/j.bbr.2025.115753
Robson Salviano de Matos, Paulo Iury Gomes Nunes, Thiago Medeiros da Costa Daniele, Antônio Anderson Ramos de Oliveira, Bruna Rafaele Diógenes da Silva, Júlio César Chaves Nunes Filho, Pedro Felipe Carvalhedo de Bruin, Veralice Meireles Sales de Bruin
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引用次数: 0

Abstract

Previous evidence shows that Sleep Deprivation (SD) negatively affects behavior and cerebral function. Tissue neurons are compromised at the DNA and RNA level and consequently, disruption of neuronal plasticity results in dysregulation of cognitive functions. Studies show that exercise improves physical conditioning and positively affects sleep, mood and cognition. The effects of exercise on brain and behavior in association with SD remain to be further elucidated. This systematic review and meta-analysis appraised behavior and brain tissue alterations in rodents exercised before SD. Sleep deprivation was commonly induced using the flowerpot method. The partial SD protocol (REM sleep deprivation) was frequent (94.73 %), and the multiple platform method (72 h) was the most used for SD (89.47 %). Treadmill-based physical exercise was common (89.4 %) (4 or 5 times/week, 30-60 min/session). Physical exercise reversed SD-induced anxiety-like and depression-like behaviors. Specifically, BDNF concentrations were increased and 5-HT levels reduced, preventing the deleterious effects of SD. These changes occurred regardless of SD duration, exercise duration, intensity, time of day, brain region, or animal species. This meta-analysis demonstrates that there is sufficient evidence to state that engaging in exercise prior to sleep deprivation (SD) improves behavioral parameters as well as BDNF and 5-HT levels. This study significantly confirms the brain and behavioral impairments caused by SD and describes the beneficial and modulatory effects of physical exercise performed before sleep deprivation.

体育锻炼通过调节BDNF和5-羟色胺水平来预防睡眠剥夺引起的啮齿动物行为和神经生物学缺陷:一项系统综述和meta分析
先前的证据表明,睡眠剥夺会对行为和大脑功能产生负面影响。组织神经元在DNA和RNA水平上受到损害,因此,神经元可塑性的破坏导致认知功能失调。研究表明,锻炼可以改善身体状况,并对睡眠、情绪和认知产生积极影响。运动对与SD相关的大脑和行为的影响仍有待进一步阐明。本系统综述和荟萃分析评估了在SD前锻炼的啮齿动物的行为和脑组织改变。通常采用花盆法诱导睡眠剥夺。部分SD方案(REM睡眠剥夺)较为常见(94.73%),多平台法(72h)最多(89.47%)。以跑步机为基础的体育锻炼很常见(89.4%)(每周4或5次,每次30-60分钟)。体育锻炼可以逆转sd诱发的焦虑和抑郁行为。具体来说,BDNF浓度升高,5-HT水平降低,防止了SD的有害影响。这些变化与运动持续时间、运动强度、一天中的时间、大脑区域或动物种类无关。这项荟萃分析表明,有足够的证据表明,在睡眠剥夺(SD)之前进行锻炼可以改善行为参数以及BDNF和5-HT水平。本研究显著证实了睡眠不足导致的大脑和行为损伤,并描述了在睡眠剥夺前进行体育锻炼的有益和调节作用。
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来源期刊
Behavioural Brain Research
Behavioural Brain Research 医学-行为科学
CiteScore
5.60
自引率
0.00%
发文量
383
审稿时长
61 days
期刊介绍: Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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