Risk assessment of human monkeypox infections: A systematic review and meta-analysis.

IF 1.9 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in Clinical and Experimental Medicine Pub Date : 2025-08-01 DOI:10.17219/acem/203099

Yue Wang, Jianlei Wang

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引用次数: 0

Abstract

Background: Human monkeypox is a zoonotic disease with increasing global prevalence. Although several studies have identified its potential risk factors, findings remain inconsistent, highlighting the need for a systematic evaluation.

Objectives: To systematically investigate risk factors associated with human monkeypox infections using meta-analysis.

Material and methods: A comprehensive search of PubMed, Scopus, Web of Science, Embase, and The Cochrane Library databases was conducted on all records up to February 19, 2024. Eligible studies assessing risk factors for monkeypox were included. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated, and heterogeneity was evaluated using I2 statistics.

Results: Of the 1,844 articles identified, 9 studies met the inclusion criteria after screening, no publication bias was identified, and the meta-analysis results showed strong robustness. Human immunodeficiency virus (HIV) infection significantly increased monkeypox risk (OR = 2.21, 95% CI: 1.13-4.34, p = 0.02, I2 = 93%). Concurrent sexually transmitted infections (STIs) were also a significant risk factor (OR = 1.84, 95% CI: 1.46-2.33), as was body mass index (BMI) higher than 30 kg/m2 (OR = 1.18, 95% CI: 0.19-7.53, p = 0.86), lower economic status (OR = 0.33, 95% CI: 0.01-9.36, p = 0.52), education level (OR = 0.74, 95% CI: 0.30-1.79, p = 0.50), or men who have sex with men (MSM) status (OR = 1.22, 95% CI: 0.84-1.75, p = 0.29).

Conclusion: HIV infection and concurrent STIs significantly increase monkeypox risk, underscoring the need for targeted prevention, including screening and risk reduction strategies in vulnerable populations, particularly MSM.

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人类猴痘感染的风险评估：系统回顾和荟萃分析。

背景：人类猴痘是一种在全球范围内日益流行的人畜共患疾病。虽然一些研究已经确定了其潜在的风险因素，但结果仍然不一致，强调需要进行系统的评估。目的：利用荟萃分析系统地调查与人类猴痘感染相关的危险因素。材料和方法：综合检索PubMed、Scopus、Web of Science、Embase和Cochrane Library数据库，检索截止到2024年2月19日的所有记录。纳入了评估猴痘危险因素的合格研究。计算比值比（ORs）和95%置信区间（95% ci），并采用I2统计评估异质性。结果：纳入1844篇文献，筛选后9篇符合纳入标准，未发现发表偏倚，meta分析结果稳健性强。人类免疫缺陷病毒（HIV）感染显著增加猴痘风险（OR = 2.21, 95% CI: 1.13-4.34, p = 0.02, I2 = 93%）。并发性传播感染（STIs）也是重要的危险因素（OR = 1.84, 95% CI: 1.46-2.33），体重指数（BMI）高于30 kg/m2 (OR = 1.18, 95% CI: 0.19-7.53, p = 0.86)，较低的经济地位（OR = 0.33, 95% CI: 0.01-9.36, p = 0.52），教育水平（OR = 0.74, 95% CI: 0.30-1.79, p = 0.50），或男性与男性发生性关系（MSM）状态（OR = 1.22, 95% CI: 0.84-1.75, p = 0.29）。结论：艾滋病毒感染和并发性传播感染显著增加猴痘风险，强调需要有针对性的预防，包括在弱势人群，特别是男同性恋者中进行筛查和降低风险策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Clinical and Experimental Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

3.70

自引率

4.80%

发文量

153

审稿时长

6-12 weeks

期刊介绍： Advances in Clinical and Experimental Medicine has been published by the Wroclaw Medical University since 1992. Establishing the medical journal was the idea of Prof. Bogumił Halawa, Chair of the Department of Cardiology, and was fully supported by the Rector of Wroclaw Medical University, Prof. Zbigniew Knapik. Prof. Halawa was also the first editor-in-chief, between 1992-1997. The journal, then entitled "Postępy Medycyny Klinicznej i Doświadczalnej", appeared quarterly. Prof. Leszek Paradowski was editor-in-chief from 1997-1999. In 1998 he initiated alterations in the profile and cover design of the journal which were accepted by the Editorial Board. The title was changed to Advances in Clinical and Experimental Medicine. Articles in English were welcomed. A number of outstanding representatives of medical science from Poland and abroad were invited to participate in the newly established International Editorial Staff. Prof. Antonina Harłozińska-Szmyrka was editor-in-chief in years 2000-2005, in years 2006-2007 once again prof. Leszek Paradowski and prof. Maria Podolak-Dawidziak was editor-in-chief in years 2008-2016. Since 2017 the editor-in chief is prof. Maciej Bagłaj. Since July 2005, original papers have been published only in English. Case reports are no longer accepted. The manuscripts are reviewed by two independent reviewers and a statistical reviewer, and English texts are proofread by a native speaker. The journal has been indexed in several databases: Scopus, Ulrich’sTM International Periodicals Directory, Index Copernicus and since 2007 in Thomson Reuters databases: Science Citation Index Expanded i Journal Citation Reports/Science Edition. In 2010 the journal obtained Impact Factor which is now 1.179 pts. Articles published in the journal are worth 15 points among Polish journals according to the Polish Committee for Scientific Research and 169.43 points according to the Index Copernicus. Since November 7, 2012, Advances in Clinical and Experimental Medicine has been indexed and included in National Library of Medicine’s MEDLINE database. English abstracts printed in the journal are included and searchable using PubMed http://www.ncbi.nlm.nih.gov/pubmed.