Peptide-driven approaches in advanced wound healing materials

Abstract

Peptide-based materials, such as antimicrobial peptides (AMPs), cell-penetrating peptides (CPPs), angiogenic peptides, and extracellular matrix (ECM)-mimetic peptides, offer unique multifunctional benefits for wound healing, including infection control, enhanced angiogenesis, immunomodulation, and tissue regeneration. Representative platforms, including hydrogels, nanofibers, functionalized dressings, and delivery systems, leverage these peptides for sustained therapeutic action and improved healing. Despite these promising advances, significant translational barriers remain, including peptide stability, enzymatic degradation, manufacturing scalability, and regulatory approval. Addressing these barriers through optimized peptide engineering and delivery strategies is essential for the clinical translation and wider clinical adoption of peptide-driven wound therapies.