Xiang Zheng , Lingxia Pang , Youpei Wang , Qianlei Zhao , Guoquan Pan , Xiaojun He , Yafeng Liang
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引用次数: 0
Abstract
Deep-seated infections caused by multidrug-resistant (MDR) bacteria, such as pneumonia and abscesses, present significant therapeutic challenges due to their complex pathological microenvironments, which often limit the efficacy of conventional antibiotic treatments. The increasing emergence of MDR bacteria, along with their ability to rapidly acquire resistance, has intensified the need for novel therapeutic strategies. The advancement of nanotechnology has facilitated the development of non-antibiotic-dependent treatment modalities, which are increasingly preferred due to their high efficiency, non-invasiveness, and resistance-free properties. In this study, guided by density functional theory (DFT) predictions, we designed an ultrasound (US)-activated bimetallic PtxRuy alloy nanozyme (PR) that synergistically combines US-activated sonodynamic therapy (SDT) with chemodynamic therapy (CDT) for precise control of reactive oxygen species (ROS) generation. By carefully optimizing the atomic ratio of platinum (Pt, catalytic sites) to ruthenium (Ru, adsorption sites), we synthesized ultrafine bimetallic alloy nanoplatforms with enhanced functional performance. Both theoretical simulations and experimental characterizations confirmed that PR exhibits exceptional oxidase-like and peroxidase-like activity, facilitating enhanced US-triggered ROS production through amplified sonodynamic effects. The PR demonstrated significant in vitro antibacterial activity, effectively disrupted biofilms, and showed excellent biocompatibility. In mouse models of pneumonia and subcutaneous abscesses, PR facilitated rapid bacterial clearance and modulation of the inflammatory microenvironment. This study presents a novel, non-antibiotic biocatalytic platform that provides a rational design strategy for bimetallic alloy nanozymes, offering a promising therapeutic approach for the synergistic treatment of MDR bacterial infections. These findings underscore the translational potential of multifunctional nanoplatforms in addressing the growing challenge of antibiotic resistance.
期刊介绍:
Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).