BIO-SPEC: An open-source bench-top parallel bioreactor system

IF 2.1 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC

HardwareX Pub Date : 2025-07-25 DOI:10.1016/j.ohx.2025.e00670

Laurens Parret , Kenneth Simoens , Jo De Vrieze , Ilse Smets

引用次数: 0

Abstract

The BIO-SPEC is an open-source, cost-effective, and modular bench-top bioreactor system designed for batch, sequencing batch, and chemostat cultivation. Featuring thermoelectric condensers to eliminate the need for a chiller, it ensures stable long-term operation. Controlled by a Raspberry Pi, the BIO-SPEC offers flexibility in headplate design, gas supply, and feeding strategies, making it a versatile alternative to high-cost commercial systems. This paper details the design, construction, and validation of the BIO-SPEC system, demonstrating its potential to advance microbiology and bioprocessing research through accessible and reliable hardware at a fraction of the cost of commercial systems.

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BIO-SPEC：一个开源的台式并行生物反应器系统

BIO-SPEC是一种开源的、具有成本效益的模块化台式生物反应器系统，专为批量、测序批量和恒化培养而设计。采用热电冷凝器，消除了对冷水机的需要，确保长期稳定运行。BIO-SPEC由树莓派控制，在头板设计、气体供应和进料策略方面具有灵活性，使其成为高成本商业系统的多功能替代方案。本文详细介绍了BIO-SPEC系统的设计、构建和验证，展示了其通过可访问和可靠的硬件推进微生物学和生物处理研究的潜力，而成本只是商业系统的一小部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

HardwareX Engineering-Industrial and Manufacturing Engineering

CiteScore

4.10

自引率

18.20%

发文量

124

审稿时长

24 weeks

期刊介绍： HardwareX is an open access journal established to promote free and open source designing, building and customizing of scientific infrastructure (hardware). HardwareX aims to recognize researchers for the time and effort in developing scientific infrastructure while providing end-users with sufficient information to replicate and validate the advances presented. HardwareX is open to input from all scientific, technological and medical disciplines. Scientific infrastructure will be interpreted in the broadest sense. Including hardware modifications to existing infrastructure, sensors and tools that perform measurements and other functions outside of the traditional lab setting (such as wearables, air/water quality sensors, and low cost alternatives to existing tools), and the creation of wholly new tools for either standard or novel laboratory tasks. Authors are encouraged to submit hardware developments that address all aspects of science, not only the final measurement, for example, enhancements in sample preparation and handling, user safety, and quality control. The use of distributed digital manufacturing strategies (e.g. 3-D printing) is encouraged. All designs must be submitted under an open hardware license.