Standardized Procedures for Blood and Cerebrospinal Fluid Collection and Storage in Neurodegenerative Biomarker Research: A Comprehensive Review.

Dementia and neurocognitive disorders Pub Date : 2025-07-01 Epub Date: 2025-07-17 DOI:10.12779/dnd.2025.24.3.162

Hyuk Sung Kwon, Geon Ha Kim, Sun Ah Park, So Young Moon, Jae-Won Jang, Kee Hyung Park, Young Ho Park, Jae-Sung Lim, Dong Won Yang, Seong Hye Choi, Byeong C Kim, SangYun Kim, Seong-Ho Koh

{"title":"Standardized Procedures for Blood and Cerebrospinal Fluid Collection and Storage in Neurodegenerative Biomarker Research: A Comprehensive Review.","authors":"Hyuk Sung Kwon, Geon Ha Kim, Sun Ah Park, So Young Moon, Jae-Won Jang, Kee Hyung Park, Young Ho Park, Jae-Sung Lim, Dong Won Yang, Seong Hye Choi, Byeong C Kim, SangYun Kim, Seong-Ho Koh","doi":"10.12779/dnd.2025.24.3.162","DOIUrl":null,"url":null,"abstract":"<p><p>Blood and cerebrospinal fluid (CSF) biomarkers are essential tools for the rapid diagnosis and monitoring of neurodegenerative diseases like Alzheimer's disease (AD). However, even minor variations in sample collection and storage procedures can significantly impact biomarker measurements, emphasizing the importance of standardized operating procedures. This review discusses the main pre-analytical factors that influence biomarker stability, outlines the best practices for blood and CSF collection and storage, and extensively analyzes recent research findings to ensure optimal reproducibility in biomarker studies. It also discusses the future directions and recommendations for enhancing biomarker research methodologies, including advancements in automated processing and quality control measures.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"24 3","pages":"162-173"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310336/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dementia and neurocognitive disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12779/dnd.2025.24.3.162","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/17 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Blood and cerebrospinal fluid (CSF) biomarkers are essential tools for the rapid diagnosis and monitoring of neurodegenerative diseases like Alzheimer's disease (AD). However, even minor variations in sample collection and storage procedures can significantly impact biomarker measurements, emphasizing the importance of standardized operating procedures. This review discusses the main pre-analytical factors that influence biomarker stability, outlines the best practices for blood and CSF collection and storage, and extensively analyzes recent research findings to ensure optimal reproducibility in biomarker studies. It also discusses the future directions and recommendations for enhancing biomarker research methodologies, including advancements in automated processing and quality control measures.

Abstract Image

查看原文本刊更多论文

神经退行性生物标志物研究中血液和脑脊液采集和储存的标准化程序：综合综述。

血液和脑脊液（CSF）生物标志物是快速诊断和监测阿尔茨海默病（AD）等神经退行性疾病的重要工具。然而，即使是样品收集和储存程序的微小变化也会显著影响生物标志物的测量，强调标准化操作程序的重要性。本文讨论了影响生物标志物稳定性的主要分析前因素，概述了血液和脑脊液收集和储存的最佳实践，并广泛分析了最近的研究结果，以确保生物标志物研究的最佳可重复性。它还讨论了未来的方向和建议，以加强生物标志物的研究方法，包括自动化处理和质量控制措施的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Dementia and neurocognitive disorders

自引率

0.00%

发文量