Assessment of Postoperative Pain After Single- or Multiple-Visit Endodontic Therapy and Its Molecular Aspects: A Randomised Controlled Study.

IF 1.5 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Australian Endodontic Journal Pub Date : 2025-08-01 DOI:10.1111/aej.12982

Larissa Nunes Rosa Bedene, Denise Piotto Leonardi, Joana Santana Couto, Bruno Marques-da-Silva, Marilisa Carneiro Leão Gabardo, João Arnando Brancher, Flávia Sens Fagundes Tomazinho

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引用次数: 0

Abstract

This study aimed to compare patients' perception of postoperative pain following single- and multiple-visit endodontic therapy, and to evaluate associations between anxiety and genetic polymorphisms in the DRD2, ANKK1 and COMT genes. In this clinical trial, 67 patients were included in the first phase (34 single visit, 33 multiple visits), and 25 participated in the second phase. Saliva was collected for genetic analysis, and the State-Trait Anxiety Inventory was applied preoperatively. Postoperative pain (presence and intensity) was recorded at 24, 48 and 72 h. The number of visits was not associated with postoperative pain (p = 0.806); pain intensity was highest at 24 h in both groups (p < 0.001). Moderate anxiety was significantly associated (p < 0.05) with pain in single- and multiple-visit. A genetic association was observed between the COMT rs174675 polymorphism and the outcome (p = 0.018), with greater pain reported by individuals with the CT genotype. (#RBR-47ngbg3).

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评估单次或多次牙髓治疗后的术后疼痛及其分子方面：一项随机对照研究。

本研究旨在比较患者在接受单次和多次牙髓治疗后对术后疼痛的感知，并评估焦虑与DRD2、ANKK1和COMT基因遗传多态性之间的关系。在本临床试验中，67例患者参加了第一期（单次来访34例，多次来访33例），25例患者参加了第二期。采集唾液进行基因分析，术前使用状态-特质焦虑量表。术后疼痛（存在和强度）分别于24、48和72小时记录。就诊次数与术后疼痛无相关性（p = 0.806）；两组疼痛强度均在24 h时最高(p

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来源期刊

Australian Endodontic Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.50

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： The Australian Endodontic Journal provides a forum for communication in the different fields that encompass endodontics for all specialists and dentists with an interest in the morphology, physiology, and pathology of the human tooth, in particular the dental pulp, root and peri-radicular tissues. The Journal features regular clinical updates, research reports and case reports from authors worldwide, and also publishes meeting abstracts, society news and historical endodontic glimpses. The Australian Endodontic Journal is a publication for dentists in general and specialist practice devoted solely to endodontics. It aims to promote communication in the different fields that encompass endodontics for those dentists who have a special interest in endodontics.