Unveiling the Diagnostic Mystery: ¹⁸F-FDG PET and Bone Scan Negative in Bone Metastases of Lobular Breast Cancer: A Case Report.

IF 1.1 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Molecular Imaging and Radionuclide Therapy Pub Date : 2025-10-08 Epub Date: 2025-08-01 DOI:10.4274/mirt.galenos.2025.75875

Sharjeel Usmani, Khulood Al Riyami, Anjali Jain, Asiya Al Busaidi, Paul Dumasig, Vipin V Jayakrishnan, Subhash Kheruka, Najeeb Ahmed

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Abstract

Identifying osseous metastases by imaging is essential and may be challenging in patients with lobular breast cancer. We present a case of a 66-year-old woman with lobular breast cancer who underwent ¹⁸F- fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) for staging purposes. ¹⁸F-FDG PET/CT reveals minimal FDG uptake in the primary tumor cells. Prominent sclerotic lesions with low FDG avidity are seen in the spinal and pelvic bones. The subsequent Tc-99m methylene diphosphonate bone scan is unremarkable. The magnetic resonance imaging (MRI) reveals bone metastases. MRI may be beneficial in invasive lobular carcinoma. MRI facilitates improved metastatic evaluation, especially in bone-only and bone-predominant metastatic malignancies, when assessment with ¹⁸F-FDG PET/CT may be difficult and constrained.

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揭示诊断之谜：18F-FDG PET和骨扫描阴性小叶乳腺癌骨转移1例报告。

通过影像学识别骨转移是必要的，对小叶乳腺癌患者可能具有挑战性。我们报告了一位66岁的小叶性乳腺癌患者，她接受了18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG PET/CT）进行分期。18F-FDG PET/CT显示原发肿瘤细胞中FDG摄取极少。脊柱和骨盆骨可见明显的硬化性病变，FDG密度低。随后的Tc-99m二膦酸亚甲基骨扫描结果并不显著。磁共振多重成像（MRI）显示骨转移。MRI对浸润性小叶癌可能是有益的。当18F-FDG PET/CT评估可能困难且受限时，MRI有助于改善转移性评估，特别是在仅骨和骨为主的转移性恶性肿瘤中。

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来源期刊

Molecular Imaging and Radionuclide Therapy RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Molecular Imaging and Radionuclide Therapy (Mol Imaging Radionucl Ther, MIRT) is publishes original research articles, invited reviews, editorials, short communications, letters, consensus statements, guidelines and case reports with a literature review on the topic, in the field of molecular imaging, multimodality imaging, nuclear medicine, radionuclide therapy, radiopharmacy, medical physics, dosimetry and radiobiology.