Harnessing Neuroplasticity: The Role of Priming in Enhancing Post Stroke Motor Function.

IF 1.6 4区医学 Q4 NEUROSCIENCES

Restorative neurology and neuroscience Pub Date : 2025-08-01 DOI:10.1177/09226028251358162

Sangeetha Madhavan

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引用次数: 0

Abstract

Stroke remains a leading cause of disability worldwide, highlighting the need for innovative neurorehabilitation strategies to enhance recovery. Recent advancements emphasize neuroplasticity-the brain's ability to reorganize and form new connections-through targeted interventions. Among these, cortical priming has emerged as a promising approach to enhance neuroplasticity and improve motor recovery post-stroke by modulating brain excitability for optimal motor learning. This review explores the role of cortical priming in stroke rehabilitation, highlighting its ability to enhance neural excitability and plasticity in motor-related brain regions. Various priming techniques, including non-invasive brain stimulation (rTMS, tDCS), deep brain stimulation (DBS), vagus nerve stimulation (VNS), brain-computer interfaces (BCIs), movement-based priming, aerobic exercise, and sensory stimulation, are examined. Despite promising findings, challenges remain in optimizing protocols and addressing individual variability. Future directions focus on biomarker-driven rehabilitation, personalized strategies, and large-scale trials to integrate cortical priming into clinical practice.

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利用神经可塑性：启动在增强脑卒中后运动功能中的作用。

中风仍然是世界范围内致残的主要原因，强调需要创新的神经康复策略来加强康复。最近的进展强调神经可塑性——大脑重组和形成新连接的能力——通过有针对性的干预。其中，皮层启动已成为一种有希望的方法，通过调节大脑兴奋性来实现最佳运动学习，从而增强神经可塑性和改善中风后的运动恢复。这篇综述探讨了皮层启动在脑卒中康复中的作用，强调了其在脑运动相关区域增强神经兴奋性和可塑性的能力。各种启动技术，包括非侵入性脑刺激（rTMS, tDCS），脑深部刺激（DBS），迷走神经刺激（VNS），脑机接口（bci），基于运动的启动，有氧运动和感觉刺激，进行了检查。尽管有很好的发现，但在优化方案和解决个体差异方面仍然存在挑战。未来的方向将集中在生物标志物驱动的康复、个性化策略和将皮质启动整合到临床实践中的大规模试验上。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Restorative neurology and neuroscience 医学-神经科学

CiteScore

5.40

自引率

3.60%

发文量

审稿时长

>12 weeks

期刊介绍： This interdisciplinary journal publishes papers relating to the plasticity and response of the nervous system to accidental or experimental injuries and their interventions, transplantation, neurodegenerative disorders and experimental strategies to improve regeneration or functional recovery and rehabilitation. Experimental and clinical research papers adopting fresh conceptual approaches are encouraged. The overriding criteria for publication are novelty, significant experimental or clinical relevance and interest to a multidisciplinary audience. Experiments on un-anesthetized animals should conform with the standards for the use of laboratory animals as established by the Institute of Laboratory Animal Resources, US National Academy of Sciences. Experiments in which paralytic agents are used must be justified. Patient identity should be concealed. All manuscripts are sent out for blind peer review to editorial board members or outside reviewers. Restorative Neurology and Neuroscience is a member of Neuroscience Peer Review Consortium.