Quantitative ultrasound-derived fat fraction for identifying pediatric patients with metabolic dysfunction-associated steatotic liver disease: a prospective study.

IF 2.3 3区医学 Q2 PEDIATRICS

Pediatric Radiology Pub Date : 2025-08-01 DOI:10.1007/s00247-025-06349-5

Yunlin Huang, Chao Sun, Juan Cheng, Ying Wang, Yijie Qiu, Shiwen Wang, Ming Wang, Li Wei, Rui Cheng, Jian-Gao Fan, Yi Dong

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引用次数: 0

Abstract

Background: Metabolic dysfunction-associated steatotic liver disease is increasingly affecting younger populations. Ultrasound-derived fat fraction is a technique used in ultrasound to quantify liver fat content. The diagnostic performance of ultrasound-derived fat fraction in pediatric patients with metabolic dysfunction-associated steatotic liver disease is yet to be evaluated.

Objective: To evaluate the diagnostic performance of ultrasound-derived fat fraction measurement in detecting and grading hepatic steatosis in pediatric patients with metabolic dysfunction-associated steatotic liver disease.

Materials and methods: In this prospective study, pediatric patients diagnosed with metabolic dysfunction-associated steatotic liver disease were enrolled. Six acquisitions of ultrasound-derived fat fraction were obtained. Taking magnetic resonance imaging (MRI)-proton density fat fraction as a reference standard, the area under the receiver operating characteristic curve (AUC) was performed to evaluate the diagnostic performance of ultrasound-derived fat fraction. Youden index was used to determine the cutoff value of ultrasound-derived fat fraction. Correlation coefficient and Bland-Altman plot were performed.

Results: From April 2024 to March 2025, 32 patients (median age, 12 years; median body mass index, 29.7 kg/m²) were included. The ultrasound-derived fat fraction values showed a positive correlation with MRI-proton density fat fraction (r = 0.72). The ultrasound-derived fat fraction values and MRI-proton density fat fraction had a mean bias of 3.3% (95% limits of agreement: -16.4, 23.1). Using MRI-proton density fat fractions ≥ 5%, ≥ 15%, and ≥ 25% as the reference standard for diagnosing hepatic steatosis grade ≥ S1, ≥ S2, and S3, the AUCs of ultrasound-derived fat fraction were 0.84, 0.88, and 0.88, with the cutoff values of 9.5%, 10.5%, and 12.8%, respectively.

Conclusion: Ultrasound-derived fat fraction demonstrates promising diagnostic performance for detecting and grading hepatic steatosis in pediatric patients with metabolic dysfunction-associated steatotic liver disease within this cohort.

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定量超声来源的脂肪部分用于识别儿童患者代谢功能障碍相关的脂肪变性肝病：一项前瞻性研究

背景：代谢功能障碍相关的脂肪变性肝病越来越多地影响到年轻人群。超声提取脂肪分数是一种用于定量肝脏脂肪含量的超声技术。超声来源的脂肪部分在儿童代谢功能障碍相关脂肪变性肝病患者中的诊断性能尚待评估。目的：评价超声脂肪含量测定在儿童代谢功能障碍相关脂肪性肝病患者肝脂肪变性检测及分级中的诊断价值。材料和方法：在这项前瞻性研究中，诊断为代谢功能障碍相关脂肪变性肝病的儿科患者被纳入研究对象。获得了6个超声来源的脂肪部分。以磁共振成像(MRI)-质子密度脂肪分数为参考标准，计算受者工作特征曲线下面积（AUC），评价超声来源脂肪分数的诊断效能。采用约登指数确定超声来源脂肪分数的临界值。进行相关系数和Bland-Altman图分析。结果：2024年4月至2025年3月，32例患者(中位年龄12岁；中位体重指数为29.7 kg/m2)。超声衍生脂肪分数值与mri质子密度脂肪分数呈正相关（r = 0.72）。超声衍生脂肪分数值和mri质子密度脂肪分数的平均偏差为3.3%（95%一致限：-16.4,23.1）。以mri质子密度脂肪分数≥5%、≥15%、≥25%作为诊断肝脂肪变性≥S1、≥S2、S3级的参考标准，超声来源脂肪分数的auc分别为0.84、0.88、0.88，临界值分别为9.5%、10.5%、12.8%。结论：在这个队列中，超声来源的脂肪部分在检测和分级代谢功能障碍相关的脂肪性肝病的儿科患者的肝脏脂肪变性方面显示出有希望的诊断性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Radiology 医学-核医学

CiteScore

4.40

自引率

17.40%

发文量

300

审稿时长

3-6 weeks

期刊介绍： Official Journal of the European Society of Pediatric Radiology, the Society for Pediatric Radiology and the Asian and Oceanic Society for Pediatric Radiology Pediatric Radiology informs its readers of new findings and progress in all areas of pediatric imaging and in related fields. This is achieved by a blend of original papers, complemented by reviews that set out the present state of knowledge in a particular area of the specialty or summarize specific topics in which discussion has led to clear conclusions. Advances in technology, methodology, apparatus and auxiliary equipment are presented, and modifications of standard techniques are described. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.