Role of miRNA‑214‑3p in cancer (Review).

IF 3.9 3区医学 Q2 ONCOLOGY

Oncology reports Pub Date : 2025-10-01 Epub Date: 2025-08-01 DOI:10.3892/or.2025.8957

Zeshan Chen, Xin Deng, Yuanhong Lu, Ling Lu, Yijue Qin, Haishun Qu, Shaohang Lan

{"title":"Role of miRNA‑214‑3p in cancer (Review).","authors":"Zeshan Chen, Xin Deng, Yuanhong Lu, Ling Lu, Yijue Qin, Haishun Qu, Shaohang Lan","doi":"10.3892/or.2025.8957","DOIUrl":null,"url":null,"abstract":"<p><p>microRNA‑214‑3p (miRNA‑214‑3p) can be mapped to the human chromosome 1q24.3 and is ~22 nucleotides in length. It has been garnering considerable attention due to its aberrant expression profile in various different types of cancer and its apparent role in regulating tumor progression. In malignant tumors, miRNA‑214‑3p can serve as a tumor suppressor or oncogene. This can be mediated by mainly inhibiting the expression of target genes by binding to the 3'‑untranslated region of target mRNAs, thereby regulating multiple downstream cellular processes, such as cell proliferation, metastasis, invasion and apoptosis. However, the role of miRNA‑214‑3p in cancer remains unclear. Therefore, in the present review, the role of miRNA‑214‑3p in cancer was summarized, whilst analyzing its potential as a biomarker for cancer diagnosis, prognosis and response to treatment. In addition, the present review evaluates its effects on sensitivity to chemotherapy, targeted therapy and radiotherapy. The current proposed strategies for the systemic delivery of miRNA‑214‑3p in cancer were also discussed.</p>","PeriodicalId":19527,"journal":{"name":"Oncology reports","volume":"54 4","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12340666/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oncology reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3892/or.2025.8957","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/1 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

microRNA‑214‑3p (miRNA‑214‑3p) can be mapped to the human chromosome 1q24.3 and is ~22 nucleotides in length. It has been garnering considerable attention due to its aberrant expression profile in various different types of cancer and its apparent role in regulating tumor progression. In malignant tumors, miRNA‑214‑3p can serve as a tumor suppressor or oncogene. This can be mediated by mainly inhibiting the expression of target genes by binding to the 3'‑untranslated region of target mRNAs, thereby regulating multiple downstream cellular processes, such as cell proliferation, metastasis, invasion and apoptosis. However, the role of miRNA‑214‑3p in cancer remains unclear. Therefore, in the present review, the role of miRNA‑214‑3p in cancer was summarized, whilst analyzing its potential as a biomarker for cancer diagnosis, prognosis and response to treatment. In addition, the present review evaluates its effects on sensitivity to chemotherapy, targeted therapy and radiotherapy. The current proposed strategies for the systemic delivery of miRNA‑214‑3p in cancer were also discussed.

查看原文本刊更多论文

miRNA - 214 - 3p在癌症中的作用（综述）。

microRNA - 214 - 3p （miRNA - 214 - 3p）可以定位到人类染色体1q24.3上，长度约为22个核苷酸。由于其在各种不同类型的癌症中的异常表达及其在调节肿瘤进展中的明显作用，它已经引起了相当大的关注。在恶性肿瘤中，miRNA - 214 - 3p可以作为肿瘤抑制基因或癌基因。这主要是通过结合靶mrna的3′-非翻译区抑制靶基因的表达，从而调控细胞增殖、转移、侵袭和凋亡等多种下游细胞过程来实现的。然而，miRNA - 214 - 3p在癌症中的作用尚不清楚。因此，本文综述了miRNA - 214 - 3p在癌症中的作用，并分析了其作为癌症诊断、预后和治疗反应的生物标志物的潜力。此外，本综述还评价了其对化疗、靶向治疗和放疗敏感性的影响。我们还讨论了目前提出的在癌症中全身递送miRNA - 214 - 3p的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Oncology reports 医学-肿瘤学

CiteScore

8.50

自引率

2.40%

发文量

187

审稿时长

3 months

期刊介绍： Oncology Reports is a monthly, peer-reviewed journal devoted to the publication of high quality original studies and reviews concerning a broad and comprehensive view of fundamental and applied research in oncology, focusing on carcinogenesis, metastasis and epidemiology.