Causal Associations of Gestational and Perinatal Factors with the Risk of Childhood Obesity: A Mendelian Randomization Study.

IF 4.7 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Obesity Facts Pub Date : 2025-07-31 DOI:10.1159/000547280

Shuidi Lin, Fangfang Lin, Zhen Lin, Wenhong Cai, Yanli Ren

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引用次数: 0

Abstract

Introduction: This study was to explore the causal association between gestational and perinatal factors and the risk of childhood obesity based on two-sample Mendelian randomization (MR).

Methods: The single-nucleotide polymorphisms (SNPs) associated with exposure were selected. MR Egger regression was used for the evaluation of the horizontal pleiotropy in SNPs. F-statistic reflects the strength of instrumental variables. Cochran's Q statistic was used to investigate the heterogeneity of SNPs. The primary MR method exploring the causal association between gestational and perinatal factors and the risk of childhood obesity was inverse variance weighted (IVW). Leave-one-out analysis was employed to identify whether the MR results were affected by single SNPs. Odds ratio (OR) and 95% confidence interval (CI) were imputed.

Results: IVW indicated that birth weight was a risk factor for childhood body mass index (BMI) (OR = 1.347, 95% CI: 1.212-1.498) and childhood obesity (OR = 1.793, 95% CI: 1.300-2.473). Increased risk of childhood obesity was identified in mother with gestational diabetes (OR = 1.059, 95% CI: 1.006-1.116). Gestational diabetes was causally related to elevated childhood BMI. Gestational diabetes was causally related to elevated risk of childhood obesity (OR = 1.249, 95% CI: 1.044-1.495).

Conclusions: Birth weight and gestational diabetes were causally related to childhood BMI and childhood obesity.

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妊娠期和围产期因素与儿童肥胖风险的因果关系：一项孟德尔随机研究。

前言：本研究旨在探讨基于双样本孟德尔随机化（MR）的妊娠期和围产期因素与儿童肥胖风险之间的因果关系。方法：选择与暴露相关的单核苷酸多态性（snp）。采用MR Egger回归评价snp的水平多效性。f统计量反映了工具变量的强度。采用Cochran’s Q统计量分析snp的异质性。探索妊娠期和围产期因素与儿童肥胖风险之间因果关系的主要MR方法是逆方差加权（IVW）。采用留一分析来确定MR结果是否受到单个snp的影响。计算了比值比（OR）和95%置信区间（CI）。结果：IVW显示出生体重是儿童体重指数（BMI）（OR=1.347, 95%CI: 1.212 ~ 1.498）和儿童肥胖（OR=1.793, 95%CI: 1.300 ~ 2.473）的危险因素。妊娠期糖尿病母亲的儿童肥胖风险增加（OR=1.059, 95%CI: 1.006-1.116）。妊娠期糖尿病与儿童BMI升高有因果关系。妊娠期糖尿病与儿童肥胖风险升高有因果关系（OR=1.249, 95%CI: 1.044-1.495）。结论：出生体重和妊娠期糖尿病与儿童BMI和儿童肥胖有因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Facts 医学-内分泌学与代谢

CiteScore

6.80

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Obesity Facts'' publishes articles covering all aspects of obesity, in particular epidemiology, etiology and pathogenesis, treatment, and the prevention of adiposity. As obesity is related to many disease processes, the journal is also dedicated to all topics pertaining to comorbidity and covers psychological and sociocultural aspects as well as influences of nutrition and exercise on body weight. The editors carefully select papers to present only the most recent findings in clinical practice and research. All professionals concerned with obesity issues will find this journal a most valuable update to keep them abreast of the latest scientific developments.