Clinical and Humanistic Burden of Adult Obesity in Asia–Pacific: A Systematic Literature Review

IF 4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in Therapy Pub Date : 2025-08-01 DOI:10.1007/s12325-025-03324-2

Esther Artime, Sarah Zimner-Rapuch, Roger Chen, Qiuhe Ji, Ichiro Tatsuno, Rachel S. Newson, Tomotaka Shingaki, Si Si, Rachel Kewley, Sam Riley, Swarna Khare

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Abstract

Introduction

Obesity continues to be an increasing global health concern. However, the burden of obesity within the Asia–Pacific (APAC) region is less well defined relative to Western countries.

Methods

A systematic literature review was conducted to characterise disease burden in people with obesity within the APAC region (defined as body mass index of ≥ 30 kg/m² in Australia and Taiwan, ≥ 28 kg/m² in China, and ≥ 25 kg/m² in Japan, Korea, and Hong Kong). The presence of obesity-related complications and impact of obesity on patient-reported outcomes is described.

Results

Complications were reported at significantly higher rates in people with obesity compared to people with a normal weight. Diabetes, hypertension, dyslipidaemia, and cardiovascular diseases were the most frequently reported obesity-related complications, and rates among people with obesity were as high as 57%, 72%, 65%, and 23% respectively. Low scores on patient-reported outcome measures indicated reduced health-related quality of life (HRQoL) among people with obesity, with lower HRQoL in those with a higher obesity class. Psychological distress was also elevated in people with obesity which persisted despite treatment.

Conclusion

Despite variation in the definition of obesity across countries in the APAC region, obesity was consistently associated with notable presence of related metabolic, cardiovascular, and psychological complications. Obesity substantially impacts psychosocial and emotional wellbeing and is associated with a reduced HRQoL in people with obesity. This highlights the need to proactively recognise and manage obesity as a chronic relapsing disease to improve the health of people with obesity. Further research is warranted to address identified evidence gaps in the APAC region.

Graphical Abstract

查看原文本刊更多论文

亚太地区成人肥胖的临床和人文负担：系统文献综述。

导读：肥胖继续成为全球日益关注的健康问题。然而，与西方国家相比，亚太地区的肥胖负担没有得到很好的界定。方法：对亚太地区肥胖人群的疾病负担特征进行了系统的文献综述（澳大利亚和台湾定义为体重指数≥30 kg/m2，中国定义为体重指数≥28 kg/m2，日本、韩国和香港定义为体重指数≥25 kg/m2）。肥胖相关并发症的存在和肥胖对患者报告结果的影响被描述。结果：肥胖人群的并发症发生率明显高于正常体重人群。糖尿病、高血压、血脂异常和心血管疾病是最常见的肥胖相关并发症，肥胖者的发病率分别高达57%、72%、65%和23%。患者报告的结果测量的低分表明肥胖患者的健康相关生活质量（HRQoL）降低，肥胖程度较高的患者的HRQoL较低。肥胖人群的心理困扰也有所增加，尽管接受了治疗，但这种情况仍然存在。结论：尽管亚太地区各国对肥胖的定义存在差异，但肥胖始终与相关代谢、心血管和心理并发症的显著存在相关。肥胖严重影响社会心理和情感健康，并与肥胖者的HRQoL降低有关。这突出表明需要积极认识和管理肥胖作为一种慢性复发疾病，以改善肥胖患者的健康。有必要进行进一步的研究，以解决亚太地区已确定的证据差距。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Therapy 医学-药学

CiteScore

7.20

自引率

2.60%

发文量

353

审稿时长

6-12 weeks

期刊介绍： Advances in Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all therapeutic areas. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Advances in Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.