Plasma fatty acid composition predicts bone mineral accrual from childhood to adolescence: the PANIC study.

IF 5.9 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Timo A Lakka, Saara Heinonen, Taisa Sallinen, Aino-Maija Eloranta, Suvi Laamanen, Annie M Skinner, Eero A Haapala, Dimitris Vlachopoulos, Alan R Barker, Toni Rikkonen, Tomi P Laitinen, Jyrki Ågren, Sonja Soininen
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Abstract

Little is known about the associations of plasma fatty acids with bone mineral accrual, and the evidence is mostly based on cross-sectional data. In this observational study, we investigated for the first time the longitudinal associations of plasma fatty acid composition as well as desaturase and elongase enzyme activities with bone mineral density (BMD) from childhood to adolescence. Altogether, 480 children (227 girls) aged 7-9 yr attending baseline examinations were included in the current analyses. The longitudinal associations of the proportions of fatty acids in plasma phospholipids, analyzed by gas chromatography, as well as estimated desaturase and elongase activities with total body less head BMD, measured by dual-energy X-ray absorptiometry, were analyzed by linear mixed-effects models using values from baseline, 2-yr, and 8-yr follow-up and adjusted for sex, maturity offset, follow-up time, and lean mass or fat mass. Decreased proportion of linoleic acid (standardized regression coefficient β = -.023, p = .001), increased proportion of dihomo-gamma-linolenic acid (β = .029, p < .001), and Δ6-desaturase activity (β = .032, p < .001) were associated with increased BMD independent of sex, maturity offset, follow-up time, lean mass, and fat mass. Increased proportions of nervonic acid (β = .018, p = .012), arachidonic acid (β = .019, p = .017), and docosapentaenoic acid (β = .020, p = .013) were associated with increased BMD, and these associations were partly explained by lean mass. Increased proportions of arachidic acid (β = .022, p = .005), behenic acid (β = .018, p = .010), lignoceric acid (β = .015, p = .040), and palmitoleic acid (β = .016, p = .013), increased stearoyl-CoA-desaturase activity (β = .017, p = .009), and decreased elongase activity (β = -.017, p = .023) were associated with increased BMD, and these associations were partly explained by fat mass. Single plasma saturated, monounsaturated, and polyunsaturated fatty acids have divergent longitudinal associations with BMD from childhood to adolescence. Plasma fatty acid composition predicts bone mineral accrual from childhood to adolescence, implying that fatty acid metabolism is important for healthy bone development since childhood.

血浆脂肪酸组成预测从儿童到青少年的骨矿物质积累:PANIC研究。
关于血浆脂肪酸与骨矿物质积累之间的关系,我们所知甚少,证据主要是基于横断面数据。在这项观察性研究中,我们首次调查了血浆脂肪酸组成以及去饱和酶和延长酶活性与骨密度(BMD)从儿童期到青春期的纵向关系。共有480名7-9岁参加基线检查的儿童(227名女孩)被纳入目前的分析。通过气相色谱法分析血浆磷脂中脂肪酸比例的纵向关联,以及通过双能x射线吸收仪测量的去饱和酶和延长酶活性与总体头部骨密度的估计,通过线性混合效应模型分析,使用基线、2年和8年随访的值,并根据性别、成熟度偏移、随访时间和瘦体重或脂肪体重进行调整。亚油酸比例降低(标准化回归系数β = -)。023, p = .001),二同γ -亚麻酸比例增加(β =。029页
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来源期刊
Journal of Bone and Mineral Research
Journal of Bone and Mineral Research 医学-内分泌学与代谢
CiteScore
11.30
自引率
6.50%
发文量
257
审稿时长
2 months
期刊介绍: The Journal of Bone and Mineral Research (JBMR) publishes highly impactful original manuscripts, reviews, and special articles on basic, translational and clinical investigations relevant to the musculoskeletal system and mineral metabolism. Specifically, the journal is interested in original research on the biology and physiology of skeletal tissues, interdisciplinary research spanning the musculoskeletal and other systems, including but not limited to immunology, hematology, energy metabolism, cancer biology, and neurology, and systems biology topics using large scale “-omics” approaches. The journal welcomes clinical research on the pathophysiology, treatment and prevention of osteoporosis and fractures, as well as sarcopenia, disorders of bone and mineral metabolism, and rare or genetically determined bone diseases.
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