Global, Regional, and National Burden of Ischaemic Stroke Attributed to High Fasting Plasma Glucose: An Analysis of Data From 1990 to 2021

IF 6 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes/Metabolism Research and Reviews Pub Date : 2025-08-02 DOI:10.1002/dmrr.70071

Hua Xue, Yuqi Zeng, Xinyang Zou, Yongkun Li

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Abstract

Background

The role of high fasting plasma glucose (HFPG) in ischaemic stroke (IS) has become increasingly prominent. Our study aimed to assess the global and regional distribution of the burden of IS attributable to HFPG (IS-HFPG) and to predict the disease burden of IS-HFPG to 2041.

Methods

This study extracted the data on the burden of IS-HFPG, including the number and age-standardized rate of deaths and disability-adjusted life years (DALYs) from the Global Burden of Disease Study (GBD) 2021. Joinpoint analysis was used to assess trends in IS-HFPG burden between 1990 and 2021. Further analyses were stratified by region, sex, and age groups.

Results

In 2021, the number of deaths and DALYs related to IS-HFPG reached 0.65 million and 12.37 million, respectively. From 1990 to 2021, the global age-standardized mortality rate (ASMR) and DALY (ASDR) for IS-HFPG declined, with an Average Annual Percentage Change (AAPC) of −0.96 (95% CI: −1.06, −0.86) and −0.72 (95% CI: −0.81, −0.62), respectively. Regionally, the ASMR and ASDR were highest in High-middle SDI and lowest in High SDI. ASMR were higher for males than for females, with rates of 9.43 per 100,000 (95% UI: 7.31, 11.75) and 7.07 per 100,000 (95% UI: 5.35, 8.96), respectively. Age-stratified analysis indicates that the elderly population, particularly those over 70 years old, bears the heaviest burden.

Conclusions

Our research indicates that the global ASMR and ASDR attributable to IS-HFPG has a declining trend. However, developing regions confront a burden of mortality and disability associated with IS-HFPG. Notably, male and the elderly are the primary demographics affected by IS-HFPG. Our study underscores the necessity for regions to formulate targeted prevention and treatment strategies that address the specific needs of diverse populations, particularly in low- and middle-income countries.

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高空腹血糖导致的全球、地区和国家缺血性卒中负担：1990年至2021年数据分析

高空腹血糖（HFPG）在缺血性脑卒中（IS）中的作用越来越突出。本研究旨在评估IS-HFPG （IS-HFPG）的全球和地区负担分布，并预测到2041年IS-HFPG的疾病负担。方法本研究从全球疾病负担研究（GBD） 2021中提取IS-HFPG负担数据，包括死亡人数、年龄标准化死亡率和残疾调整生命年（DALYs）。联合点分析用于评估1990年至2021年间IS-HFPG负担的趋势。进一步的分析按地区、性别和年龄组进行分层。结果2021年与IS-HFPG相关的死亡人数和DALYs分别达到65万和1237万。从1990年到2021年，IS-HFPG的全球年龄标准化死亡率（ASMR）和DALY （ASDR）下降，平均年百分比变化（AAPC）分别为- 0.96 （95% CI: - 1.06, - 0.86）和- 0.72 （95% CI: - 0.81, - 0.62）。从区域来看，高-中等SDI地区的ASMR和ASDR最高，高SDI地区的ASMR和ASDR最低。男性ASMR高于女性，分别为9.43 / 10万（95% UI: 7.31、11.75）和7.07 / 10万（95% UI: 5.35、8.96）。年龄分层分析表明，老年人口，特别是70岁以上的老年人，负担最重。结论IS-HFPG导致的全球ASMR和ASDR呈下降趋势。然而，发展中地区面临着与IS-HFPG相关的死亡和残疾负担。值得注意的是，男性和老年人是受IS-HFPG影响的主要人群。我们的研究强调了各地区制定有针对性的预防和治疗战略的必要性，以满足不同人群的具体需求，特别是在低收入和中等收入国家。

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来源期刊

Diabetes/Metabolism Research and Reviews 医学-内分泌学与代谢

CiteScore

17.20

自引率

2.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Diabetes/Metabolism Research and Reviews is a premier endocrinology and metabolism journal esteemed by clinicians and researchers alike. Encompassing a wide spectrum of topics including diabetes, endocrinology, metabolism, and obesity, the journal eagerly accepts submissions ranging from clinical studies to basic and translational research, as well as reviews exploring historical progress, controversial issues, and prominent opinions in the field. Join us in advancing knowledge and understanding in the realm of diabetes and metabolism.