Corrigendum to “Preclinical evaluation of the safety and effectiveness of a new bioartificial cornea” [Bioact. Mater. 2023 (8) 29 265–278]

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2025-08-01 DOI:10.1016/j.bioactmat.2025.07.011

Yansha Hao , Jingting Zhou , Ju Tan , Feng Xiang , Zhongliang Qin , Jun Yao , Gang Li , Mingcan Yang , Lingqin Zeng , Wen Zeng , Chuhong Zhu

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引用次数: 0

Abstract

Cross-linking agents are frequently used to restore corneal properties after decellularization, and it is especially important to select an appropriate method to avoid excessive cross-linking. In addition, how to promote wound healing and how to improve scar formation require further investigation. To ensure the safety and efficacy of animal-derived products, we designed bioartificial corneas (BACs) according to the criteria for Class III medical devices. Our BACs do not require cross-linking agents and increase mechanical strength via self-cross-linking of aldehyde-modified hyaluronic acid (AHA) and carboxymethyl chitosan (CMC) on the surface of decellularized porcine corneas (DPCs). The results showed that the BACs had good biocompatibility and transparency, and the modification enhanced their antibacterial and anti-inflammatory properties in vitro. Preclinical animal studies showed that the BACs can rapidly regenerate the epithelium and restore vision within a month. After 3 months, the BACs were gradually filled with epithelial, stromal, and neuronal cells, and after 6 months, their transparency and histology were almost normal. In addition, side effects such as corneal neovascularization, conjunctival hyperemia, and ciliary body hyperemia rarely occur in vivo. Therefore, these BACs show promise for clinical application for the treatment of infectious corneal ulcers and as a temporary covering for corneal perforations to achieve the more time.

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“一种新型生物人工角膜的安全性和有效性的临床前评估”[Bioact.]更正。材料，2023 (8)29 265-278]

在角膜脱细胞后，经常使用交联剂来恢复角膜的特性，选择合适的方法来避免过度的交联尤为重要。此外，如何促进创面愈合，如何改善瘢痕形成还需进一步研究。为了保证动物源性产品的安全性和有效性，我们按照第三类医疗器械的标准设计了生物人工角膜（BACs）。我们的BACs不需要交联剂，通过醛修饰透明质酸（AHA）和羧甲基壳聚糖（CMC）在脱细胞猪角膜（DPCs）表面的自交联来提高机械强度。结果表明，BACs具有良好的生物相容性和透明性，体外抗菌和抗炎性能增强。临床前动物研究表明，bac能在一个月内迅速再生上皮并恢复视力。3个月后，BACs逐渐充满上皮细胞、间质细胞和神经元细胞，6个月后，BACs的透明度和组织学基本正常。此外，角膜新生血管、结膜充血、睫状体充血等副作用在体内很少发生。因此，这些bac在治疗感染性角膜溃疡和作为角膜穿孔的临时覆盖物以获得更多的时间方面具有临床应用前景。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.