Altered Blood Pressure Reflexes in Women With Endometriosis.

Abstract

BACKGROUND Endometriosis is a risk factor for cardiovascular disease. COX (Cyclooxygenase) is upregulated in endometriotic lesions, potentially exaggerating pressor reflexes, a major risk factor for adverse cardiovascular events. The purpose of this study was to determine whether women with endometriosis demonstrate exaggerated pressor responses. We hypothesized that women with endometriosis would show exaggerated BP compared with healthy women during handgrip exercise and cold pressor testing (CPT). METHODS In a single-blind, randomized, crossover design, women with (Endo ; n=11) and without (HC; n=9) endometriosis underwent a CPT and handgrip with postexercise ischemia following aspirin (a nonselective COX inhibitor; 650 mg) or placebo. Blood pressure was continuously monitored during baseline (5 minutes) and hand submersion (3 minutes; 4-8 °C) during CPT, and during baseline (5 minutes), 30% maximal voluntary contraction handgrip (2 minutes), and postexercise ischemia (3 minutes) for handgrip with postexercise ischemia. RESULTS Women with endometriosis demonstrated attenuated pressor responses to CPT (∆MAP Endo 21±16 versus HC 34±20 mm Hg; P<0.01) and handgrip with postexercise ischemia (handgrip/postexercise ischemia: ΔMAP Endo=12±13/13±10 mm Hg, HC=24±14/20±8 mm Hg; P<0.01). There was no effect of aspirin on blood pressure response to either CPT or handgrip with postexercise ischemia. CONCLUSIONS Compared with age-matched HC, women with endometriosis demonstrate lower increases in blood pressure in response to cold exposure and exercise. Aspirin, a COX inhibitor, had no impact on these responses. Collectively, these results suggest that women with endometriosis demonstrate altered central integration and attenuated sympathetic outflow and end-organ responsiveness.