Neural Activation Down to the Spinal Cord during Action Language? A Transcranial Magnetic Stimulation and Peripheral Nerve Stimulation Study.

Abstract

Language comprehension is increasingly recognized as extending beyond the traditional linguistic system to engage motor and perceptual processes. This perspective is supported by numerous studies demonstrating that understanding action-related words often induces behavioral and neurophysiological changes in the motor system. However, it remains unclear whether the influence of action language on the motor system is restricted to cortical regions or whether it also extends to spinal structures, as observed during motor imagery. To address this, we used TMS and peripheral nerve stimulation to assess corticospinal excitability and cortico-motoneuronal transmission, respectively. Fifteen healthy and right-handed volunteers participated in four conditions: (i) rest, (ii) kinesthetic motor imagery of finger and wrist flexion, (iii) reading action sentences, and (iv) reading nonaction sentences. As anticipated, corticospinal excitability increased during both kinesthetic motor imagery and action reading compared to rest. Interestingly, although kinesthetic motor imagery also led to the expected increase in cortico-motoneuronal transmission, no such modulation occurred during action reading. These findings suggest that action reading do not modulate the excitability of high-threshold motoneurons at the spinal level, contrary to motor imagery. Further investigation is needed to test whether action reading activates lower-threshold spinal structures, such as interneurons involved in spinal presynaptic inhibition.