The Mediating Role of Activities of Daily Living in the Relationship Between Depressive Symptoms and Multidimensional Frailty in the Elderly with Multimorbidity.

IF 3.7 3区医学 Q2 GERIATRICS & GERONTOLOGY

Clinical Interventions in Aging Pub Date : 2025-07-26 eCollection Date: 2025-01-01 DOI:10.2147/CIA.S518492

Dongmei Mei, Yan Yang, Defang Meng, Yaoyao Hu, Xiaoyan Wang

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引用次数: 0

Abstract

Purpose: Previous studies have shown an association between depression and frailty in older adults, but the psychological and social dimensions of frailty are often overlooked, especially in the context of multimorbidity. This study aims to explore the association of depressive symptoms with multidimensional frailty and the mediating role of ADL.

Patients and methods: Data were collected using a general information questionnaire, Tilburg Frailty Indicator (TFI), ADL was assessed with Barthel index, and Elderly Depression Rating Scale.

Results: Depressive symptoms were significantly correlated with multidimensional frailty (including each dimension) and ADL (p <0.05). Regression analysis showed that depressive symptoms were directly associated with multidimensional frailty (β = 0.484, p < 0.001) and indirectly through ADL (β = 0.442, p < 0.001). Dimensions showed that depressive symptoms directly associated with physical frailty and mental frailty (β = 0.454, 0.542, 0.118, p < 0.001) indirectly through ADLs (β = 0.250, 0.492, p < 0.001). Bootstrap tests confirmed the robustness of these findings.

Conclusion: The findings confirm the importance of interventions targeting mental health and restoration of physical function to prevent multidimensional frailty in older adults with multimorbidity.

Abstract Image

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日常生活活动在老年多病患者抑郁症状与多维虚弱关系中的中介作用

目的：先前的研究表明，老年人抑郁与虚弱之间存在关联，但虚弱的心理和社会层面往往被忽视，特别是在多病的背景下。本研究旨在探讨抑郁症状与多维脆弱的关系以及ADL的中介作用。患者和方法：采用一般信息问卷，Tilburg衰弱指数（TFI）， Barthel指数和老年抑郁评定量表评估ADL。结果：抑郁症状与多维虚弱（包括各维度）和ADL有显著相关（p < 0.001），并通过ADL间接相关（β = 0.442, p < 0.001）。维度显示，抑郁症状与身体虚弱和精神虚弱直接相关（β = 0.454, 0.542, 0.118, p < 0.001），通过ADLs间接相关（β = 0.250, 0.492, p < 0.001）。Bootstrap测试证实了这些发现的稳健性。结论：研究结果证实了针对心理健康和身体功能恢复的干预措施对预防多重疾病老年人多维虚弱的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.80

自引率

2.80%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.