Considerations for informing precision psychiatry in eating disorders: Foundations for future practice.

IF 4.5 3区 医学 Q2 NUTRITION & DIETETICS
Nicole Obeid, Niana Lavallée, Abigail H M Bradley, Mark L Norris
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引用次数: 0

Abstract

Eating disorders (EDs) are multisystemic, debilitating, and complex illnesses that affect many young Canadians. These disorders are associated with high rates of medical complications, psychiatric and physical comorbidities, functional impairment, family distress, and financial burden. Despite the severity and increasing prevalence of EDs in youth, advancements in understandings of the pathophysiology and treatment of EDs have remained limited over the past three decades. This trend may be shaped by the chronic underfunding of the field, reliance on small sampled cross-sectional studies, and the notable lack of research focused on youth with EDs from historically underrepresented communities. Current treatment practices demonstrate modest efficacy and often omit the complex, heterogeneous presentations, development, and maintenance of pediatric EDs. Large-scale, multiaxial datasets are necessary to elucidate ED etiology and enable phenotyping. This is a critical step towards implementing future precision psychiatry and personalized treatment advances. In this commentary, we share our experience of conceptualizing a precision ED data and bio-registry, EDBioMAP: Eating Disorder Bio-Registry and Multiaxial Precision Health Platform, and suggest necessary pillars to inform, implement, and drive the successful use of precision psychiatry in pediatric ED care. Effective data utilization requires actionable steps and includes: (1) establishing strategic partnerships; (2) incorporating measurement-based care into clinical practice; (3) collecting novel biological markers; (4) developing minimum datasets; and (5) leveraging predictive modelling techniques. Strategic and standardized data integration is imperative to informing the future use of precision psychiatry for EDs. It can lend well to igniting multi-site collaboration to enhance large datasets necessary for this type of work and offers avenues for future development of personalized treatment interventions and clinical decision-making tools for youth with EDs.

在饮食失调中告知精确精神病学的考虑:未来实践的基础。
饮食失调(EDs)是影响许多加拿大年轻人的多系统,衰弱和复杂的疾病。这些疾病与高发的医疗并发症、精神和身体合并症、功能损害、家庭痛苦和经济负担有关。尽管ed在青少年中的严重程度和患病率越来越高,但在过去的三十年中,对ed病理生理学和治疗的理解仍然有限。这一趋势可能是由于该领域长期资金不足,依赖于小样本横断面研究,以及明显缺乏对来自历史上代表性不足的社区的ed青年的研究。目前的治疗实践显示出适度的疗效,往往忽略了儿科急诊科的复杂、异质的表现、发展和维持。大规模,多轴数据集是必要的阐明ED病因和使表型。这是实现未来精准精神病学和个性化治疗进步的关键一步。在这篇评论中,我们分享了我们在概念化精确ED数据和生物登记,EDBioMAP:饮食失调生物登记和多轴精确健康平台方面的经验,并提出了必要的支柱,以告知、实施和推动精确精神病学在儿科ED护理中的成功应用。有效的数据利用需要可操作的步骤,包括:(1)建立战略伙伴关系;(2)将以测量为基础的护理纳入临床实践;(3)收集新的生物标志物;(4)开发最小数据集;(5)利用预测建模技术。战略性和标准化的数据整合是必要的,以告知未来使用精确精神病学的急诊科。它可以很好地点燃多站点协作,以增强这类工作所需的大型数据集,并为未来开发个性化治疗干预措施和为患有ed的青年提供临床决策工具提供途径。
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来源期刊
Journal of Eating Disorders
Journal of Eating Disorders Neuroscience-Behavioral Neuroscience
CiteScore
5.30
自引率
17.10%
发文量
161
审稿时长
16 weeks
期刊介绍: Journal of Eating Disorders is the first open access, peer-reviewed journal publishing leading research in the science and clinical practice of eating disorders. It disseminates research that provides answers to the important issues and key challenges in the field of eating disorders and to facilitate translation of evidence into practice. The journal publishes research on all aspects of eating disorders namely their epidemiology, nature, determinants, neurobiology, prevention, treatment and outcomes. The scope includes, but is not limited to anorexia nervosa, bulimia nervosa, binge eating disorder and other eating disorders. Related areas such as important co-morbidities, obesity, body image, appetite, food and eating are also included. Articles about research methodology and assessment are welcomed where they advance the field of eating disorders.
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