Proton pump inhibitors and mortality in patients with cancer: Unraveling the complex link.

IF 3.2 Q3 ONCOLOGY
Ibtehaj Tariq, Qurat Ul Ain Iftikhar, Abdulqadir J Nashwan
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引用次数: 0

Abstract

Proton pump inhibitors (PPIs) are widely utilized in oncology to treat gastroesophageal reflux disease, peptic ulcer disease, and chemotherapy-induced mucosal injury. Emerging evidence has suggested that prolonged use of PPIs is associated with increased mortality in patients with cancer. The findings of Krishnan et al are proof of this but need to be considered cautiously due to potential confounding factors. This letter raised important methodological concerns, including confounding by indication, reverse causality, and polypharmacy that can influence the observed association. While PPIs are important in oncology, their advantages and disadvantages should be weighed judiciously by clinicians. Future prospective studies with robust analytical approaches will be required to ascertain more definite causality.

质子泵抑制剂与癌症患者死亡率:解开复杂的联系。
质子泵抑制剂(PPIs)广泛应用于肿瘤治疗胃食管反流病、消化性溃疡病和化疗引起的粘膜损伤。新出现的证据表明,长期使用质子泵抑制剂与癌症患者死亡率增加有关。Krishnan等人的发现证明了这一点,但由于潜在的混杂因素,需要谨慎考虑。这封信提出了重要的方法学问题,包括适应症的混淆、反向因果关系和可能影响观察到的关联的多种药物。虽然质子泵抑制剂在肿瘤学中很重要,但临床医生应审慎权衡其利弊。未来的前瞻性研究将需要强有力的分析方法来确定更明确的因果关系。
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来源期刊
自引率
0.00%
发文量
585
期刊介绍: The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.
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