Perceived risk of gastric cancer associated with long-term use of proton pump inhibitors: Bridging the gap.

IF 3.2 Q3 ONCOLOGY
Ibrahim O Sawaied, Abraham O Samson, Efrat Golan
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引用次数: 0

Abstract

Background: Long-term use of proton pump inhibitors (PPIs) has been associated with potential adverse effects, including an increased risk of gastric cancer. Despite widespread use awareness of these risks among physicians varies considerably. Understanding physicians' perceptions and prescribing behaviors is critical to improving patient safety and promoting evidence-based practices. This study aimed to assess the level of awareness and risk perception among gastroenterologists and non-gastroenterologists regarding prolonged PPI use and its association with gastric malignancy.

Aim: To assess physicians' awareness of gastric cancer risk associated with long-term PPI use and compare perceptions between specialties.

Methods: A cross-sectional observational study was conducted among 33 physicians (15 gastroenterologists and 18 non-gastroenterologists) in Israel. Participants completed a structured questionnaire evaluating knowledge, attitudes, and prescribing behaviors related to PPI use. Data were analyzed using descriptive statistics and nonparametric tests to assess differences between groups and correlation patterns. Ethical approval and informed consent were obtained.

Results: Gastroenterologists demonstrated significantly higher awareness of the potential gastric cancer risks linked to prolonged PPI use (mean awareness score: 6.9 ± 1.2) compared with non-gastroenterologists (4.1 ± 1.3, P < 0.01). Despite their awareness 80% of gastroenterologists reported frequent long-term prescribing. Nonparametric correlation analysis revealed associations between specialty, knowledge level, and prescribing habits. Several misconceptions about cancer risk mechanisms were identified across specialties.

Conclusion: Physician awareness regarding gastric cancer risk of long-term PPI use remains inconsistent, especially among non-specialists, emphasizing the need for targeted educational programs and clearer prescribing guidelines.

与长期使用质子泵抑制剂相关的胃癌感知风险:弥合差距。
背景:长期使用质子泵抑制剂(PPIs)与潜在的不良反应相关,包括胃癌的风险增加。尽管广泛使用,但医生对这些风险的认识差异很大。了解医生的看法和处方行为对于改善患者安全和促进循证实践至关重要。本研究旨在评估胃肠病学家和非胃肠病学家对长期使用PPI及其与胃恶性肿瘤的关系的认识水平和风险感知。目的:评估医师对长期使用PPI相关胃癌风险的认知,并比较不同专业医师的认知。方法:在以色列的33名医生(15名胃肠病学家和18名非胃肠病学家)中进行了一项横断面观察研究。参与者完成了一份结构化问卷,评估与PPI使用相关的知识、态度和处方行为。使用描述性统计和非参数检验分析数据,以评估组间差异和相关模式。获得了伦理批准和知情同意。结果:胃肠科医师对长期使用PPI相关的潜在胃癌风险的认知(平均认知得分:6.9±1.2)明显高于非胃肠科医师(平均认知得分:4.1±1.3,P < 0.01)。尽管他们意识到了这一点,但80%的胃肠病学家报告了频繁的长期处方。非参数相关分析显示专业、知识水平和处方习惯之间存在关联。在各专业中发现了一些关于癌症风险机制的误解。结论:医生对长期使用PPI的胃癌风险的认识仍然不一致,特别是在非专科医生中,强调需要有针对性的教育计划和更明确的处方指南。
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来源期刊
自引率
0.00%
发文量
585
期刊介绍: The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.
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