A combination of potential psychobiotics alleviates anxiety and depression behaviors induced by chronic unpredictable mild stress.

IF 9.2 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2025-07-30 DOI:10.1038/s41522-025-00779-7

Chen Meng, Siyuan Feng, Zikai Hao, Hong Liu

引用次数: 0

Abstract

Strains of Roseburia inulinivorans, Bacteroides uniformis, and Eubacterium rectale have exhibited multi-pathway therapeutic efficacy against anxiety and depression-like behaviors in chronic unpredictable mild stress (CUMS) rats. However, the combined therapeutic effects of these strains remain to be elucidated. Behavioral tests showed that a mixture of these strains reduced anxiety and depression-like behaviors. 16S rRNA sequencing revealed that the mixtures decrease the relative abundance of potentially pathogenic bacteria within the gut microbiota. Furthermore, the mixture increased the levels of butyric, isobutyric, and isovaleric acids in the gut and decreased pro-inflammatory factors in serum. It also lowered diamine oxidase, histamine in brain tissue, increased DL-kynurenine, and reduced cortisol secretion by the hypothalamic pituitary adrenal axis. In summary, the mixture significantly alleviated anxiety and depression-like behaviors.

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潜在的心理生物制剂组合可减轻慢性不可预测的轻度压力引起的焦虑和抑郁行为。

在慢性不可预测轻度应激（CUMS）大鼠中，红玫瑰菌、均匀拟杆菌和直肠真杆菌菌株对焦虑和抑郁样行为表现出多途径的治疗效果。然而，这些菌株的联合治疗效果仍有待阐明。行为测试表明，这些压力的混合减少了焦虑和抑郁样行为。16S rRNA测序显示，这些混合物降低了肠道微生物群中潜在致病菌的相对丰度。此外，该混合物增加了肠道中丁酸、异丁酸和异戊酸的水平，降低了血清中的促炎因子。它还能降低脑组织中的二胺氧化酶、组胺，增加dl -犬尿氨酸，减少下丘脑-垂体-肾上腺轴分泌的皮质醇。综上所述，这种混合物显著缓解了焦虑和抑郁样行为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.