Intracellular cholesterol: new functions and therapeutic approaches in NSCLC EGFR-TKI resistance.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2025-07-30 DOI:10.1186/s12944-025-02559-w

Linjuan Wang, Yue Qiu, Xiang Huang, Shimei Zhang, Min Zhao, Qiufang Chen

引用次数: 0

Abstract

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have markedly enhanced survival rates among patients with advanced non-small cell lung cancer (NSCLC) exhibiting EGFR mutations. However, acquired resistance diminishes their therapeutic efficacy over time. Recent investigations have linked intracellular cholesterol with the emergence and advancement of various cancers. Elevated cholesterol levels could correlate with resistance to EGFR-TKIs in NSCLC. This review examines the association between cholesterol and EGFR-TKI resistance in NSCLC, with the objective of identifying more effective treatments and surmounting resistance.

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细胞内胆固醇：NSCLC EGFR-TKI耐药的新功能和治疗途径

表皮生长因子受体酪氨酸激酶抑制剂（EGFR- tkis）可显著提高EGFR突变的晚期非小细胞肺癌（NSCLC）患者的生存率。然而，随着时间的推移，获得性耐药性降低了它们的治疗效果。最近的研究将细胞内胆固醇与各种癌症的发生和发展联系起来。高胆固醇水平可能与NSCLC对EGFR-TKIs的耐药性相关。本综述探讨了非小细胞肺癌中胆固醇与EGFR-TKI耐药之间的关系，目的是确定更有效的治疗方法和克服耐药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.