Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease.

IF 5 3区 医学 Q2 NEUROSCIENCES
Kayenat Parveen, J Alexander Ross, Hendrik van der Wurp, Monika Balzer-Geldsetzer, Daniela Berg, Günther Deuschl, Thomas Gasser, Rüdiger Hilker-Roggendorf, Elke Kalbe, Inga Liepelt-Scarfone, Brit Mollenhauer, Oliver Riedel, Sandra Röske, Jörg B Schulz, Annika Spottke, Alexander Storch, Claudia Trenkwalder, Jan Kassubek, Karsten Witt, Richard Dodel, Ullrich Wüllner, Alfredo Ramirez, Maria Carolina Dalmasso
{"title":"Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease.","authors":"Kayenat Parveen, J Alexander Ross, Hendrik van der Wurp, Monika Balzer-Geldsetzer, Daniela Berg, Günther Deuschl, Thomas Gasser, Rüdiger Hilker-Roggendorf, Elke Kalbe, Inga Liepelt-Scarfone, Brit Mollenhauer, Oliver Riedel, Sandra Röske, Jörg B Schulz, Annika Spottke, Alexander Storch, Claudia Trenkwalder, Jan Kassubek, Karsten Witt, Richard Dodel, Ullrich Wüllner, Alfredo Ramirez, Maria Carolina Dalmasso","doi":"10.1177/1877718X251356512","DOIUrl":null,"url":null,"abstract":"<p><p>Parkinson's disease (PD) is marked by motor symptoms and often accompanied by mild cognitive impairment (PD-MCI), affecting up to 50% of patients and preceding PD dementia (PDD). Genetic factors may influence this progression, yet the underlying mechanisms remain unclear. This study investigated genetic factors influencing the progression from PD-MCI to PDD using polygenic risk scores (PRS). A genome-wide association study (GWAS) was conducted using data from the LANDSCAPE study. Multivariable Cox regression, Kaplan-Meier survival analysis, and concordance statistics assessed the relationship between PRS and PDD progression. No significant association was found between PD PRS and the risk of developing PDD.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1877718X251356512"},"PeriodicalIF":5.0000,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Parkinson's disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/1877718X251356512","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Parkinson's disease (PD) is marked by motor symptoms and often accompanied by mild cognitive impairment (PD-MCI), affecting up to 50% of patients and preceding PD dementia (PDD). Genetic factors may influence this progression, yet the underlying mechanisms remain unclear. This study investigated genetic factors influencing the progression from PD-MCI to PDD using polygenic risk scores (PRS). A genome-wide association study (GWAS) was conducted using data from the LANDSCAPE study. Multivariable Cox regression, Kaplan-Meier survival analysis, and concordance statistics assessed the relationship between PRS and PDD progression. No significant association was found between PD PRS and the risk of developing PDD.

帕金森痴呆症的进展不受阿尔茨海默病或帕金森病的遗传风险变异的调节。
帕金森病(PD)以运动症状为特征,通常伴有轻度认知障碍(PD- mci),影响多达50%的患者,并伴有PD痴呆(PDD)。遗传因素可能影响这一进展,但潜在的机制尚不清楚。本研究利用多基因风险评分(PRS)研究影响PD-MCI向PDD进展的遗传因素。使用LANDSCAPE研究的数据进行了全基因组关联研究(GWAS)。多变量Cox回归、Kaplan-Meier生存分析和一致性统计评估了PRS与PDD进展之间的关系。未发现PD PRS与PDD发病风险之间存在显著关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
8.40
自引率
5.80%
发文量
338
审稿时长
>12 weeks
期刊介绍: The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信