Kayenat Parveen, J Alexander Ross, Hendrik van der Wurp, Monika Balzer-Geldsetzer, Daniela Berg, Günther Deuschl, Thomas Gasser, Rüdiger Hilker-Roggendorf, Elke Kalbe, Inga Liepelt-Scarfone, Brit Mollenhauer, Oliver Riedel, Sandra Röske, Jörg B Schulz, Annika Spottke, Alexander Storch, Claudia Trenkwalder, Jan Kassubek, Karsten Witt, Richard Dodel, Ullrich Wüllner, Alfredo Ramirez, Maria Carolina Dalmasso
{"title":"Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease.","authors":"Kayenat Parveen, J Alexander Ross, Hendrik van der Wurp, Monika Balzer-Geldsetzer, Daniela Berg, Günther Deuschl, Thomas Gasser, Rüdiger Hilker-Roggendorf, Elke Kalbe, Inga Liepelt-Scarfone, Brit Mollenhauer, Oliver Riedel, Sandra Röske, Jörg B Schulz, Annika Spottke, Alexander Storch, Claudia Trenkwalder, Jan Kassubek, Karsten Witt, Richard Dodel, Ullrich Wüllner, Alfredo Ramirez, Maria Carolina Dalmasso","doi":"10.1177/1877718X251356512","DOIUrl":null,"url":null,"abstract":"<p><p>Parkinson's disease (PD) is marked by motor symptoms and often accompanied by mild cognitive impairment (PD-MCI), affecting up to 50% of patients and preceding PD dementia (PDD). Genetic factors may influence this progression, yet the underlying mechanisms remain unclear. This study investigated genetic factors influencing the progression from PD-MCI to PDD using polygenic risk scores (PRS). A genome-wide association study (GWAS) was conducted using data from the LANDSCAPE study. Multivariable Cox regression, Kaplan-Meier survival analysis, and concordance statistics assessed the relationship between PRS and PDD progression. No significant association was found between PD PRS and the risk of developing PDD.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1877718X251356512"},"PeriodicalIF":5.0000,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Parkinson's disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/1877718X251356512","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Parkinson's disease (PD) is marked by motor symptoms and often accompanied by mild cognitive impairment (PD-MCI), affecting up to 50% of patients and preceding PD dementia (PDD). Genetic factors may influence this progression, yet the underlying mechanisms remain unclear. This study investigated genetic factors influencing the progression from PD-MCI to PDD using polygenic risk scores (PRS). A genome-wide association study (GWAS) was conducted using data from the LANDSCAPE study. Multivariable Cox regression, Kaplan-Meier survival analysis, and concordance statistics assessed the relationship between PRS and PDD progression. No significant association was found between PD PRS and the risk of developing PDD.
期刊介绍:
The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.