Sociodemographic and clinical correlates of markers of immune activation, exhaustion and platelet activation among HIV-infected patients initiating antiretroviral therapy in Dar es Salaam, Tanzania.

IF 1.1 4区 医学 Q4 INFECTIOUS DISEASES
Tosi Michael Mwakyandile, Grace Ambrose Shayo, Philip Galula Sasi, Ferdinand Mukama Mugusi, Godfrey Barabona, Takamasa Ueno, Eligius Francis Lyamuya
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Abstract

Chronic inflammation and persistent immune activation (IA) during HIV infection are associated with non-AIDS complications. We investigated sociodemographic and clinical characteristics influencing IA and exhaustion (IE), and platelet activation (PA) in newly diagnosed people living with HIV (PLHIV) and identified modifiable factors for early interventions. We analysed baseline blood samples from 365 PLHIV participating in a trial investigating the effect of aspirin on IA, IE, and PA. We assessed levels of markers of monocyte activation (soluble CD14), platelet activation (soluble P-selectin), T-cell activation (CD4⁺ and CD8⁺ expressing CD69 and co-expressing CD38 and HLA-DR), and T-cell exhaustion (PD-1). The median (IQR) age of the participants was 37 (28, 45) years, with females comprising 64.7%. Advanced age significantly predicted IA and IE, but not PA. Markers of IA and IE, but not of PA, inversely correlated with CD4 counts, while directly with HIV viral load (HVL). We show that most Tanzanian PLHIV initiating antiretroviral therapy (ART) have low CD4 count, high HVL, with a considerable proportion aged above 50 years, characteristics associated with heightened IA and IE. Adjunctive therapy, when available, should target such population and at ART initiation to prevent morbidity and mortality associated with persistent IA and IE.

坦桑尼亚达累斯萨拉姆开始抗逆转录病毒治疗的艾滋病毒感染患者中免疫激活、衰竭和血小板激活标志物的社会人口学和临床相关性
HIV感染期间的慢性炎症和持续免疫激活(IA)与非艾滋病并发症有关。我们调查了影响新诊断的HIV感染者IA和衰竭(IE)以及血小板激活(PA)的社会人口学和临床特征,并确定了早期干预的可修改因素。我们分析了参加一项研究阿司匹林对IA、IE和PA影响的试验的365例PLHIV患者的基线血液样本。我们评估了单核细胞活化(可溶性CD14)、血小板活化(可溶性p -选择素)、t细胞活化(CD4 +和CD8 +表达CD69、共表达CD38和HLA-DR)和t细胞衰竭(PD-1)的标志物水平。参与者的中位(IQR)年龄为37(28,45)岁,女性占64.7%。高龄对IA和IE有显著预测作用,但对PA无显著影响。IA和IE的标志物与CD4计数呈负相关,而与HIV病毒载量(HVL)直接相关,但PA不相关。我们发现,大多数坦桑尼亚PLHIV开始抗逆转录病毒治疗(ART)时CD4计数低,HVL高,年龄在50岁以上的比例相当大,这些特征与IA和IE升高有关。辅助治疗,如果有的话,应该针对这些人群,并在抗逆转录病毒治疗开始时,以预防与持续性IA和IE相关的发病率和死亡率。
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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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