Phylogenetic analysis of the VP1 coding region of CVA6 detected in hand-foot-and-mouth disease during surveillance from 2019 to 2024 in Japan.

IF 1.1 4区医学 Q4 INFECTIOUS DISEASES

Japanese journal of infectious diseases Pub Date : 2025-07-31 DOI:10.7883/yoken.JJID.2025.039

Hiroyuki Tsukagoshi, Mami Nagashima, Kumiko Takahashi, Katsumi Mizuta, Tatsuya Ikeda, Ryo Shimada, Akira Kawase, Hiroto Shinomiya, Reiko Okamoto-Nakagawa, Komei Shirabe, Yasuo Kaburagi, Hiroyuki Ichikawa, Monami Taguchi, Sakurako Abe, Nobuhiro Saruki

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Abstract

Hand, foot, and mouth disease (HFMD) caused by enteroviruses is common in children. Recently, coxsackievirus A6 (CVA6) has been identified as a major causative agent. In this study, we conducted a phylogenetic analysis of a part of the VP1 coding region of 194 CVA6 strains detected directly from 767 nasopharyngeal swab or stool samples of HFMD patients in Japan from 2019 to 2024. The detected CVA6 strains were classified into genotype D. Moreover, the strains detected from before 2019 to 2023 belonged to cluster (cluster 1 and 2), whereas the most of strains detected in 2024 belonged to another cluster (cluster 3). Genetic identity among all detected CVA6 strains was 89.1%-100%, and genetic identity within the cluster for each detected strain was 90.6%-100% for the before 2019 (cluster 1) strains, 92.6%-100% for the 2019-2023 (cluster 2) and 94.5%-100% for the 2024 (cluster 3) strains. Most of the strains detected in 2024 were similar to the strains detected in China in 2023, suggesting that the influx of new strains caused the 2024 outbreak in Japan. HFMD is one of the most prevalent diseases in the world and its pathogenicity and antigenicity may be altered. Surveillance of the influx of new strains from outside Japan will become increasingly important.

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2019 - 2024年日本手足口病监测检测到的CVA6病毒VP1编码区系统发育分析

由肠道病毒引起的手足口病（手足口病）在儿童中很常见。最近，柯萨奇病毒A6 （CVA6）已被确定为一个主要的病原体。本研究对2019 - 2024年从日本767例手足口病患者鼻咽拭子或粪便样本中直接检测到的194株CVA6病毒VP1编码区部分进行了系统发育分析。检出的CVA6菌株均为d基因型，且2019 - 2023年之前检出的菌株属于聚类（聚类1和聚类2），而2024年检出的菌株大部分属于另一聚类（聚类3）。所有检测到的CVA6菌株的遗传同源性为89.1% ~ 100%，其中2019年之前（第1簇）菌株的遗传同源性为90.6% ~ 100%，2019-2023年（第2簇）菌株的遗传同源性为92.6% ~ 100%，2024年（第3簇）菌株的遗传同源性为94.5% ~ 100%。2024年检测到的大多数病毒株与2023年中国检测到的病毒株相似，提示新病毒株的流入导致了2024年日本的疫情。手足口病是世界上最流行的疾病之一，其致病性和抗原性是可以改变的。对从日本境外流入的新病毒株进行监测将变得越来越重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese journal of infectious diseases 医学-传染病学

CiteScore

4.50

自引率

4.50%

发文量

172

审稿时长

2 months

期刊介绍： Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.