Molecular epidemiology of measles virus re-emergence in Osaka Prefecture, Japan, after lifting COVID-19 pandemic travel restrictions.

IF 1.1 4区 医学 Q4 INFECTIOUS DISEASES
Takako Kurata, Daiki Kanbayashi, Kensaku Kakimoto, Noriyuki Otsuki, Tatsuya Miyoshi, Hideki Mizutani, Hitomi Kobayashi, Hiromi Fukuda, Miho Uesugi, Ikumi Murakami, Takeshi Kometani, Hideki Nagayama, Norihito Sugimoto, Kazushi Motomura
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引用次数: 0

Abstract

After lifting travel bans imposed during the coronavirus 2019 pandemic, the number of reported measles cases in Japan started rising, culminating in 11 cases in Osaka Prefecture in 2024. We investigated the molecular epidemiology of these cases using 450 nucleotides of the C-terminal region of the nucleoprotein gene (N-450) and the noncoding region located between the matrix and fusion protein genes (MF-NCR). N-450 analysis revealed eight cases of genotype D8 and three of B3. Seven of the D8 cases were closely related to strains from Central Asia and Europe, harboring mutations in the primer binding region targeted by real-time PCR assays for measles virus. The remaining D8 case matched a strain from Thailand. All three B3 cases were identical to the strain detected in Vietnam in 2024. MF-NCR analysis of D8 cases revealed similar trends to those observed in the N-450 analysis. However, the B3 viruses from Vietnam differed by several bases from the closest related sequence and included a 6-base insertion. Given the resurgence of measles in Vietnam since 2024, the potential risk of continuous measles importation remains. Attention should focus on measles surveillance under circumstances of increased international human interactions, specifically the Exposition 2025 Osaka, Kansai in Japan.

解除COVID-19大流行旅行限制后,日本大阪府麻疹病毒的分子流行病学再次出现。
在取消2019年冠状病毒大流行期间实施的旅行禁令后,日本报告的麻疹病例数量开始上升,2024年大阪府的麻疹病例达到11例。我们利用核蛋白基因c端区(N-450)的450个核苷酸和位于基质与融合蛋白基因之间的非编码区(MF-NCR)研究了这些病例的分子流行病学。N-450分析显示8例D8基因型和3例B3基因型。7例D8病例与来自中亚和欧洲的毒株密切相关,在麻疹病毒实时PCR检测的引物结合区存在突变。其余的D8病例与来自泰国的一种毒株相匹配。所有三个B3病例都与2024年在越南发现的菌株相同。D8病例的MF-NCR分析显示与N-450分析中观察到的趋势相似。然而,来自越南的B3病毒与最接近的相关序列有几个碱基的不同,并且包括一个6个碱基的插入。鉴于越南自2024年以来麻疹死灰复燃,持续输入麻疹的潜在风险仍然存在。在国际人际交往增加的情况下,特别是在日本关西大阪举办的2025年世博会,应将注意力集中在麻疹监测上。
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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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