Epidemiological and genetic characteristics of human astroviruses detected during acute gastroenteritis outbreaks in Yokohama, Japan, between 2017 and 2023.

IF 1.1 4区 医学 Q4 INFECTIOUS DISEASES
Makoto Kumazaki, Shuzo Usuku
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引用次数: 0

Abstract

This study aimed to investigate the epidemiological and genetic characteristics of human astroviruses (HAstVs) detected during acute gastroenteritis (AG) outbreaks in Yokohama, Japan. We collected stool samples and epidemiological information between September 2017 and August 2023 and used real-time reverse transcription (RT)-PCR and/or RT-PCR to detect HAstV from 53 samples from 20 (3.1%) of the 648 virus-associated AG outbreaks during the study period. Of the 20 outbreaks investigated via sequencing, 13 were caused by classic HAstV, three by HAstV-MLB, and four were due to multiple genotypes, classic HAstV and HAstV-MLB. The strains detected in Yokohama were found to be closely related within their respective genotypes. The distribution of HAstV genotypes differed by age groups, with HAstV1 and HAstV-MLB1 primarily found in 0-3 year-olds, whereas HAstV4 typically occurred in individuals over 4 years of age. Of the 53 HAstV-infected patients, 49 (92.5%) experienced diarrhea, with 36 exhibiting only this symptom. Vomiting (18.9%) was less prevalent than diarrhea. There were no differences in the symptoms between individuals with classic HAstV and HAstV-MLB.

2017年至2023年日本横滨急性肠胃炎暴发期间检测到的人类星状病毒的流行病学和遗传特征
本研究旨在调查日本横滨地区急性胃肠炎(AG)暴发中检测到的人类星状病毒(hastv)的流行病学和遗传特征。我们收集了2017年9月至2023年8月期间的粪便样本和流行病学信息,并使用实时反转录(RT)-PCR和/或RT-PCR检测了研究期间648例病毒相关AG暴发中的20例(3.1%)中的53例样本中的HAstV。在通过测序调查的20例暴发中,13例由经典HAstV引起,3例由HAstV- mlb引起,4例由经典HAstV和HAstV- mlb多基因型引起。在横滨检测到的菌株在其各自的基因型内密切相关。HAstV基因型的分布因年龄组而异,其中HAstV1和HAstV- mlb1主要在0-3岁儿童中发现,而HAstV4通常发生在4岁以上的个体中。在53例hav感染患者中,49例(92.5%)出现腹泻,其中36例仅表现出腹泻症状。呕吐(18.9%)的发生率低于腹泻。典型的HAstV和HAstV- mlb患者之间的症状没有差异。
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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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